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首页> 外文期刊>Journal of clinical laboratory analysis. >Determination of high‐sensitivity cardiac troponin T upper reference limits under the improved selection criteria in a Chinese population
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Determination of high‐sensitivity cardiac troponin T upper reference limits under the improved selection criteria in a Chinese population

机译：中国人口改善选择标准下的高敏感性心肌肌钙蛋白T上参考限制的测定

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Background There is no common consensus on how to define the reference population for determination of high‐sensitivity cardiac troponin (hs‐cTn) upper reference limit (URL). This study aimed to establish 99th percentile URLs of hs‐cTnT under both 2018 AACC/IFCC criteria and improved selection criteria for further judging whether two URLs are different. Methods Applying the stratified cluster sampling protocol, this study took 1848 apparently healthy subjects in communities of Shenyang China as the screening objects. We first followed 2018 AACC/IFCC criteria using surrogate biomarker for diabetes, myocardial dysfunction, renal dysfunction, and electrocardiogram. Then, we followed improved selection criteria to exclude hypertension, overweight and obesity, and dyslipidemia by physical examination and laboratory screening. Accordingly, 99th percentile URLs of hs‐cTnT were established. Results If the 2018 AACC/IFCC criteria were applied, 99th percentile URLs (90% confidence interval) of hs‐cTnT male, female, and total were 19 (17‐20)?ng/L, 16 (15‐17)?ng/L, and 18 (16‐19)?ng/L, respectively. If added a single supplementary selection criteria, 99th percentile URLs of hs‐cTnT total reduced to 16?ng/L, 17?ng/L, and 16?ng/L, respectively. If the improved selection criteria were applied, 99th percentile URLs (90% confidence interval) of hs‐cTnT male, female, and total were 18 (14‐24)?ng/L, 13 (11‐16)?ng/L, and 16 (13‐17)?ng/L, respectively. The 99th percentile URLs of hs‐cTnT male were higher than those of female in every age group. Conclusions Improved selection criteria through questionnaire survey, physical examination, and laboratory screening to further exclude hypertension, overweight and obesity, and dyslipidemia can avoid overestimation of the 99th percentile URL of hs‐cTnT.
机译：背景技术如何确定如何确定高敏感性心肌肌钙蛋白（HS-CTN）上参考限制（URL）的参考群。本研究旨在根据2018年AACC / IFCC标准建立第99百分位的HS-CTNT URL，以及改进的选择标准，以进一步判断两个URL是否不同。方法采用分层集群抽样协议，本研究采取了1848年的沉阳中国社区作为筛选物体的健康科目。我们首先遵循2018年AACC / IFCC标准，使用替代生物标志物用于糖尿病，心肌功能障碍，肾功能紊乱和心电图。然后，我们按照物理检查和实验室筛选改善了选择标准以排除高血压，超重和肥胖症和血脂异常。因此，建立了99百分位的HS-CTNT URL。结果如果应用2018年AACC / IFCC标准，则HS-CTNT雄性，女性和总量的第99个百分点URL（90％置信区间）为19（17-20）？NG / L，16（15-17）？NG / L和18（16-19）？Ng / L.如果添加了单个补充选择标准，则分别将99百分位的HS-CTNT，分别降低至16μg/ L，17℃和16μg/ L.如果应用改进的选择标准，则HS-CTNT雄性，雌性和总量的99百分位URL（90％置信区间）为18（14-24）？Ng / L，13（11-16）？Ng / L，和16（13-17）？Ng / L分别。 HS-CTNT男性的第99百分位数高于每个年龄组的女性。结论通过调查调查，体检和实验室筛查改善选择标准，以进一步排除高血压，超重和肥胖，血脂血症可以避免高估HS-CTNT的99百分位URL。

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