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首页> 外文期刊>Journal of Computers >A Rapid Quantitative Determination Method of AFP Concentration with Gold Immunochromatographic Strip
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A Rapid Quantitative Determination Method of AFP Concentration with Gold Immunochromatographic Strip

机译：黄金免疫色素条带AFP浓度的快速定量测定方法

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—Alpha-fetoprotein (AFP) is a useful diagnostic marker for the detection of a great number of infantile diseases, especially for some forms of malignant tumors and liver disorders. Although there are several methods for quantitative determination of AFP, compared with these methods, the gold immunochromatographic assay (GICA)has the advantages of easy to handle, low costs, quick, no requirement for skilled technicians and most important, well suitable for point-of-care measurements. However, GICA mostly has been used for qualitative or semi-quantitative detection visually. This paper presents a rapid quantitative determination method of AFP with GICA strip based on the reflective optical detection. Under the driving of the micro-stepper motor, we can get a curve of GICA strip signal distribution. Then after segmentation of the test line and control line using fuzzy c-means clustering algorithm, the features were extracted to be as the input features of Support Vector Regression (SVR) model. SVR was used for prediction of the AFP concentration. To evaluate the reliability and accuracy of GICA for fast quantitatively determination of AFP and its clinical value, the AFP concentration of specimen was tested by GICA and chemiluminescent immunoassay analyzer, and analyzed the coincident rate and correlation of these two methods. The experiment results demonstrated that the correlation coefficient results between the two methods was 0.961. The test results showed that the SVR model yields a good result and is proved to be appropriate in quantitative determination of AFP with GICA strip.
机译：-alpha甲胎蛋白（AFP）是用于检测婴儿疾病的大量的有用的诊断标记物，特别是对一些形式的恶性肿瘤和肝脏疾病。虽然有定量测定AFP的几种方法，这些方法相比，金免疫层析法（GICA）具有方便的优点来处理，成本低，见效快，对专业技术人员没有要求，最重要的，也适用于点对多点医护测量。然而，GICA大多已被用于定性或半定量检测直观。本文介绍了一种快速定量测定AFP与GICA条基于所述反射光检测方法。下的微步进电机的驱动，就可以得到GICA条信号分布的曲线。然后使用模糊C均值聚类算法测试线和控制线的分割后，分别提取的特征是作为支持向量回归（SVR）模型的输入功能。 SVR被用于AFP浓度的预测。为了评估GICA对AFP的快速定量测定和其临床应用价值的可靠性和准确性，试样的AFP浓度通过GICA和化学发光免疫分析仪进行测试，并分析这两种方法的一致率和相关性。实验结果表明，这两种方法之间的相关系数为结果0.961。试验结果表明，SVR模型产生了良好的结果，并且证明在定量测定AFP与GICA条为宜。

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