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首页> 外文期刊>Journal of Diabetes and Metabolic Disorders >Association of serum sestrin 2 and betatrophin with serum neutrophil gelatinase associated lipocalin levels in type 2 diabetic patients with diabetic nephropathy
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Association of serum sestrin 2 and betatrophin with serum neutrophil gelatinase associated lipocalin levels in type 2 diabetic patients with diabetic nephropathy

机译：血清中嗜中性粒细胞明胶糖苷酶相关脂质素水平的糖尿病患者糖尿病患者糖尿病肾病患者血清嗜嗜菌糖苷酶相关性

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PurposeUnderstanding the pathogenesis and the molecular mechanisms of diabetic nephropathy (DN) helps its timely detection and prevention. The current work aims tomeasure serum sestrin 2 and betatrophin levels in healthy and type diabetic (T2DM)subjects with/or without diabetic nephropathy (DN) and also to test their correlation with serum neutrophil gelatinase associated lipocalin (sNGAL); indicator of DN.MethodsThis study included 96 subjects; 20 healthy (G1) and 76 T2DM [22 normoalbuminuric (G2), 35 microalbuminuric (G3) and 19 macroalbuminuric (G4)]. Serum sestrin 2, betatrophin and NGAL were measured by their corresponding kits.ResultsSignificant low levels of serum sestrin 2 andhigh levels of serum betatrophin were found in T2DM group when compared to G1 ( p =?0.002, p ?0.001, respectively) and this difference is manifested in G4 followed, in order, by G3, G2 then G1 ( p =??0.001 for both). Also, serum sestrin2 levels showed significant negative correlations with sNGAL in G1 (r?=??0.497, p =?0.026), G2 (r?=??0.784, p ?0.001), G3 (r?=??0.894, p ?0.001) and G4 (r?=??0.896, pp.??0.001) while serum betatrophin levels showed significant positive correlations with sNGAL in G2 (r?=?0.681, p ?0.001), G3 (r?=?0.518, p ?0.001) and G4 (r?=?0.727, p ?0.001).ConclusionSerum sestrin 2 levels decrease significantly while betatrophin levels increase significantly in T2DM patients with DN especially those with macroalbuminuria. These levels have significant effect strengths on the indicator of diabetic nephropathy; sNGAL which might indicate theirvaluablerole in the timely detection and prevention of the development of DN.
机译：患有糖尿病肾病（DN）的发病机制和分子机制有助于其及时检测和预防。目前的工作旨在产生健康和型糖尿病（T2DM）受试者的可释放血清Sestrin 2和Bettrophin水平，其中包含/或不含糖尿病肾病（DN），并测试它们与血清中性粒细胞明胶酶相关脂素（SNGAL）的相关性; DN.Methodsthis研究的指标包括96个科目; 20健康（G1）和76 T2DM [22 NormoalbuminuRic（G2），35微型白蛋白酶（G3）和19种大蛋白酶（G4）]。通过它们的相应试剂盒测量血清Sestrin 2，Bettrophin和Ngal。与G1相比，在T2DM组中发现在T2DM组中发现血清Sertin 2和高水平的血清Sestrin 2和高水平的血清Bettrophin。（P = 0.002，p> 0.001）在G4中表现出差异，按顺序，通过G3，G2然后G1（两者都是β> 0.001）。此外，血清Seetrin2水平与G1中的SNGAL显着呈现出显着的负相关性（R？= 0.497，P = 0.026），G2（R？= ?? 0.784，P> 0.001），G3（R？= ?? 0.894 ，p> 0.001）和g4（r？=Δε0.001），而血清BERATROPHIN水平与G2中的SNGAL显示出显着的正相关性（R？= 0.681，P> 0.001），G3（ r？= 0.518，p> 0.001）和g4（r？=Δ0.727，p> 0.001）。Conclusionserum sestrin 2水平显着降低，而BERATROPHIN水平在T2DM患者中显着增加，尤其是具有大核细胞的DN患者。这些水平对糖尿病肾病的指标具有显着的效果强度; SNGAL可能表明他们的valuablerole在及时检测和预防DN的发展中。

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