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首页> 外文期刊>Journal of genetics >Association between the SNPs in trace element-related metabolic genes and the risk of gastric cancer: a casea??control study in Xianyou of China
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Association between the SNPs in trace element-related metabolic genes and the risk of gastric cancer: a casea??control study in Xianyou of China

机译：与痕量元素相关的代谢基因的SNP与胃癌风险的关联：Casea ??咸宇的仙气研究

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This study aims to analyse the potential relationship between single-nucleotide polymorphism (SNPs) in trace element related metabolic genes GSTM3, GSTP1, GPX1 and NKG2D and the risk of gastric cancer. A casea??control study was conducted in the hospital of Xianyou, Fujian, China. In this study, a total of 299 patients with histopathological diagnosis in gastric cancer and 295 healthy control subjects were involved. Association between the SNPs in trace element-related metabolic genes and gastric cancer risk was analysed using the unconditional logistic regression model. No relationship was found between the SNPs of GSTM3 and GPX1 genes and gastric cancer risk. However, the risk of gastric cancer is related to the SNPs of NKG2D gene (rs1049174). Patients who carry the rs1049174 GG genotype have a higher incidence of the gastric cancer and a multivariate odds ratio (OR) of 1.85 (95% confidence intervals (CI): 1.02a??3.38). Through haplotype analysis, two haplotypes (i.e. A_rs1746123-T_rs10431294-G_rs1049174 and T_rs1746123-T_rs10431294-C_rs1049174), OR of 0.29 (95% CI: 0.15a??0.56) and 0.33, (95% CI: 0.22a??0.50), respectively, were found to have lower incidence of gastric cancer. Meanwhile, another two haplotypes (T_rs1746123-C_rs10431294-C_rs1049174 and T_rs1746123-T_rs10431294-G_rs1049174), OR of 1.81 (95% CI: 1.40a??2.34) and 3.09 (95% CI: 2.30a??4.16), respectively, were found to have a higher incidence of gastric cancer. Further, no influence of the haplotype on the risk of cardia gastric cancer was found. However, the haplotype T_rs1746123-T_rs10431294-C_rs1049174 had lower incidence of noncardia gastric cancer by 46%. Our data showed that polymorphisms of trace element-related metabolic genes are important in gastric cancer pathology.
机译：本研究旨在分析微量元素相关代谢基因GSTM3，GSTP1，GPX1和NKG2D的单核苷酸多态性（SNP）与胃癌风险的潜在关系。卡西亚的对照研究是在中国福建省咸友医院进行的。在这项研究中，共有299例胃癌和295例健康对照组织病理学诊断患者。使用无条件逻辑回归模型分析了与痕量元素相关的代谢基因和胃癌风险的SNP之间的关联。在GSTM3和GPX1基因的SNP和GPX1基因和胃癌风险之间没有发现任何关系。然而，胃癌的风险与NKG2D基因的SNP有关（RS1049174）。携带RS1049174 GG基因型的患者具有胃癌的发生率较高，多元次数比（或）为1.85（95％置信区间（CI）：1.02A？3.38）。通过单倍型分析，两个单倍型（即A_RS1746123-T_RS10431294-G_RS1049174-T_RS10431294-C_RS10431294 -C_RS1049174），或0.29（95％CI：0.15A？0.56）和0.33，（95％CI：0.22A-0.50），分别发现胃癌发病率较低。同时，另外两种单倍型（T_RS1746123-C_RS10431294-C_RS1049123-T_RS10431294-G_RS10431294-G_RS1049174）分别为1.81（95％CI：1.40a -2.34）和3.09（95％CI：2.30a -4.4.15）是发现胃癌发病率较高。此外，未发现单倍型对贲门癌风险的影响。然而，单倍型T_RS1746123-T_RS10431294-C_RS1049174具有46％的非心率胃癌的发病率降低。我们的数据显示，痕量元素相关的代谢基因的多态性在胃癌病理学中是重要的。

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