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首页> 外文期刊>Journal of genetics >Genetic variant rs10937405 of TP63 and susceptibility to lung cancer risk in north Indian population
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Genetic variant rs10937405 of TP63 and susceptibility to lung cancer risk in north Indian population

机译：TP63的遗传变异RS10937405及北印度人口肺癌风险的易感性

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Several studies including genomewide association studies (GWASs) in diverse ethnic populations have reported a significant association of genetic variant rs10937405 of TP63 with nonsmall cell lung cancer (NSCLC). However, no data are available from any Indian population on the association of this variant with NSCLC. Using TaqMan genotyping chemistry, we conducted a casea??control study involving 190 NSCLC cases and 400 ethnic, age-matched controls to explore the association of rs10937405 genetic variant with NSCLC in patients from north India. Our data support that the rs10937405 variant is also significantly associated with the NSCLC and is a risk factor in the north Indian populations to develop NSCLC. However, unlike most other studies, the wild-type allele T appears to be the risk allele, as its frequency was significantly higher in the cases than controls (0.439 in cases versus 0.383 in controls. OR=1.95 (1.23a??3.09 at 95% CI); P value (adjusted)= 0.004). Genetic association was also observed by applying different genetic models. The present study provides important information of the genetic aetiology of NSCLC and strengthens GWAS findings, highlighting the role of TP63 in lung cancer risk.
机译：多种民族种群中Genomewide关联研究（GWASS）在内的几项研究报告了TP63的遗传变异RS10937405与NONSMALL细胞肺癌（NSCLC）进行了重大关联。然而，没有NSCLC的任何印度人口都没有从任何印度人提供数据。使用Taqman基因分型化学，我们进行了一种卡西亚的控制研究，涉及190个NSCLC病例和400个族裔，年龄符合对照的控制，以探讨RS10937405遗传变异与NSCLC的协会，北印度北方患者。我们的数据支持，RS10937405变体也与NSCLC显着相关，并且是北印度人口的风险因素，以发展NSCLC。然而，与大多数其他研究不同，野生型等位基因T似乎是风险等位基因，因为其频率在病例中的频率显着高于对照（0.439，在对照中的0.383时。或= 1.95（1.23A？3.09 95％CI）; P值（调整）= 0.004）。还通过应用不同的遗传模型来观察遗传结合。本研究提供了NSCLC遗传性遗传学的重要信息，并强化了GWAS发现，突出了TP63在肺癌风险中的作用。

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