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首页> 外文期刊>Journal of genetics >Gene coexpression analysis reveals dose-dependent and type-specific networks responding to ionizing radiation in the aquatic model plant Lemna minor using public data
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Gene coexpression analysis reveals dose-dependent and type-specific networks responding to ionizing radiation in the aquatic model plant Lemna minor using public data

机译:基因共表达分析显示使用公共数据的水生模型植物Lemna次要电离辐射的剂量依赖性和类型的网络

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Ionizing radiations (IRs) are widespread damaging stresses to plant growth and development. However, the regulatory networks underlying the mechanisms of responses to IRs remains poorly understood. Here, a set of publicly available transcriptomic data (conducted by Van Hoeck et al. 2015a), in which Lemna minor plants were exposed to a series of doses of gamma, beta and uranium treatments was used to perform gene coexpression network analysis. Overall, the genes involved in DNA synthesis and chromatin structure, light signalling, photosynthesis, and carbohydrate metabolism were commonly responsive to gamma, beta and uranium treatments. Genes related to anthocyanin accumulation and trichome differentiation were specifically downregulated, andgenes related to nitrogen and phosphate nutrition, cell vesicle transport, mitochondrial electron transport and ATP synthesis were specifically upregulated in response to uranium treatment. While genes involved in DNA damage and repair, RNA processing and RNA binding were specifically downregulated and genes involved in calcium signalling, redox and degradation of carbohydrate metabolism were specifically upregulated responding to gamma radiation. These findings revealed both dose-dependent and typespecific networks responding to different IRs in L. minor, and can be served as a useful resource to better understand the mechanisms of responses to different IRs in other plants.
机译:电离辐射(IRS)是植物生长和发育的危险损伤胁迫。但是,对IRS响应机制的监管网络仍然明白很差。这里,一组公开的转录组数据(由Van Hoeck等,2015A进行),其中将Lemna轻微的植物暴露于一系列剂量的γ,β和铀处理中来进行基因共表达网络分析。总的来说,参与DNA合成和染色质结构,光信号,光合作用和碳水化合物代谢的基因通常是γ,β和铀处理的敏感性。特异性下调与花青素积累和毛细血管分化有关的基因,与氮和磷酸盐营养,细胞囊泡输送,线粒体电子传输和ATP合成有关,响应于铀处理,特别地上调。虽然参与DNA损伤和修复的基因,但具体下调和参与钙信号传导,氧化还原和碳水化合物代谢的降解的基因的基因特异性地上调响应γ辐射。这些发现揭示了在L.次要的不同IRS中响应的剂量相关和类型的网络,并且可以作为更好地理解其他植物对不同IRS的响应机制的有用资源。

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