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首页> 外文期刊>Journal of Experimental Pharmacology >Alpha-Mangostin Improves Cardiac Hypertrophy and Fibrosis and Associated Biochemical Parameters in High-Fat/High-Glucose Diet and Low-Dose Streptozotocin Injection-Induced Type 2 Diabetic Rats
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Alpha-Mangostin Improves Cardiac Hypertrophy and Fibrosis and Associated Biochemical Parameters in High-Fat/High-Glucose Diet and Low-Dose Streptozotocin Injection-Induced Type 2 Diabetic Rats

机译：Alpha-mangostin改善了高脂/高葡萄糖饮食中的心脏肥大和纤维化和相关的生化参数，低剂量链脲佐菌素注射诱导的2型糖尿病大鼠

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Purpose: The aim of present study was to analyze the effect of alpha-mangostin on cardiac hypertrophy and fibrosis and biochemical parameters in high-fat/high-glucose diet and low-dose streptozotocin injection (HF/HG/STZ)-induced type 2 diabetic rats. Methods: Diabetes was induced in male Wistar rats by giving a combination of high-fat/high-glucose (HF/HG) diet for 3 weeks and followed by low-dose streptozotocin intraperitoneal injection (STZ; 35 mg/kg) at Week-3 and the HF/HG diet was continued until 8 weeks. The diabetic rats were then divided into four groups (each, n=6): untreated diabetic group (HF/HG/STZ); diabetic group treated with metformin 200 mg/kg/day (HF/HG/STZ+Metformin); diabetic group treated with alpha-mangostin 100 mg/kg/day (HF/HG/STZ+AM100); and diabetic group treated with alpha-mangostin 200 mg/kg/day (HF/HG/STZ+AM200) and all were given by oral gavage for 8 weeks. We also included a control group (C) treated with AM200 (C+AM200). The role of alpha-mangostin was assessed through its effect on blood glucose levels, HOMA-IR, blood pressure, body weight, pro-inflammatory cytokines in cardiac tissue, serum aminotransferases (ALT and AST), lipid profiles (cholesterol and triglyceride), blood urea nitrogen (BUN), uric acid, cardiac hypertrophy and fibrosis. Results: Diabetic rats treated with alpha-mangostin in both doses for 8 weeks showed decrease in blood glucose levels, HOMA-IR, and blood pressure. Alpha-mangostin treatment also prevented HF/HG/STZ-induced changes in the activities of ALT, AST, BUN, uric acid, lipid profiles, and pro-inflammatory cytokines, which were comparable with the standard drug metformin, while alpha-mangostin did not show any significant effects on control rats (p 0.05). The cardiac hypertrophy and fibrosis were also attenuated in diabetic rats treated with alpha-mangostin in both doses. Conclusion: These data suggest that administration of alpha-mangostin can effectively attenuate diabetes-induced alteration in cardiac hypertrophy and fibrosis as well as biochemical parameters in HF/HG/STZ rats.
机译：目的：目前的研究目的是分析α-血小霉素对高脂/高葡萄糖饮食中的心脏肥大和纤维化和生化参数的影响，低剂量链脲佐菌素注射（HF / HG / STZ）诱导2型糖尿病大鼠。方法：通过给予高脂/高葡萄糖（HF / HG）饮食3周，然后在周的低剂量链脲发胶（STZ; 35mg / kg）的组合，在雄性Wistar大鼠中诱导糖尿病。 3和HF / Hg饮食持续到8周。然后将糖尿病大鼠分为四组（各，n = 6）：未经处理的糖尿病基团（HF / Hg / stz）;用二甲双胍200mg / kg /天（Hf / hg / stz +二甲双胍）处理的糖尿病组;用α-山底蛋白100mg / kg /天（Hf / hg / stz + am100）处理的糖尿病组;用α-芒果蛋白200mg / kg /天（Hf / hg / stz + am200）处理的糖尿病组，并且通过口服饲喂8周给出。我们还包括用AM200处理的对照组（C）（C + AM200）。通过其对心脏组织中的血糖水平，HOMA-IR，血压，体重，血清氨基转移酶（ALT和AST），脂质曲线（胆固醇和甘油三酯）的影响来评估α-芒果蛋白的作用。血尿尿素氮（面包），尿酸，心脏肥大和纤维化。结果：血糖水平，HOMA-IR和血压两种剂量含有8周的α-芒果蛋白处理的糖尿病大鼠。 Alpha-Mangostin治疗还可以预防HF / Hg / STZ诱导的Alt，AST，BUN，尿酸，脂质曲线和促炎细胞因子的活性，与标准药物二甲双胍相当，而α-芒果蛋白酶没有显示对对照大鼠的任何显着影响（p> 0.05）。在两种剂量中用α-山底蛋白酶处理的糖尿病大鼠也衰减了心脏肥大和纤维化。结论：这些数据表明，α-芒果蛋白的给药可以有效地衰减心脏肥大和纤维化的糖尿病诱导的改变以及HF / HG / STZ大鼠的生化参数。

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