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首页> 外文期刊>Journal of infection and public health. >Clinico-epidemiological and genomic profile of first Zika Virus outbreak in India at Jaipur city of Rajasthan state
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Clinico-epidemiological and genomic profile of first Zika Virus outbreak in India at Jaipur city of Rajasthan state

机译：在斋浦尔市拉贾斯坦邦印度第一寨病毒爆发的临床流行病学和基因组曲线

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Background First Zika virus (ZIKV) positive case from North India was detected on routine surveillance of Dengue-Like Illness in an 85-year old female. Objective of the study was to conduct an investigation for epidemiological, clinical and genomic analysis of first ZIKV outbreak in Rajasthan, North India and enhance routine ZIKV surveillance. Method Outbreak investigation was performed in 3 Km radius of the index case among patient contacts, febrile cases, and pregnant women. Routine surveillance was enhanced to include samples from various districts of Rajasthan. Presence of ZIKV in serum and urine samples was detected by real time PCR test and CDC trioplex kit. Few ZIKV positive samples were sequenced using the next-generation sequencing method for genomic analysis. Result On outbreak investigation 153/2043 (7.48%) cases were found positive: 1/153 (0.65%) among contacts, 90/153 (58.8%) in fever cases, 62/153(40.5%) in pregnant females. In routine surveillance, 6/4722 (0.12%) serum samples were ZIKV positive.Majority of patients had mild signs and symptoms, no case of microcephaly and Guillain- Barre Syndrome was seen, 25 (40.3%) pregnant females delivered healthy babies, four (6.4%) reported abortion and three (4.8%) had intrauterine death, one (1.6%) child had colorectal malformation and died after few days of birth. ZIKV was found to belong to Asian lineage, mutation related to enhanced neuro-virulence and transmission in animal models was not found. Conclusion ZIKV was endogenous to India belonging to Asian Lineage. Disease profile of the ZIKV was asymptomatic to mild. No major anomaly was observed in infants born to ZIKV positive mothers; however, long term follow up of these children is required. There is need to scale up surveillance in the virology lab network of India for early detection and control. Summary line Zika virus infection was endogenous due to Asian Lineage with mild disease, no case of microcephaly or Guillain- Barre Syndrome was seen but children need to be followed for anomalies and surveillance of ZIKV needs to be enhanced in the country.
机译：背景技术来自北印度的第一个Zika病毒（Zikv）阳性案例在一个85岁的女性中检测到北印度的常规监测。该研究的目的是对Rajasthan，北印度的第一个Zikv爆发的流行病学，临床和基因组分析进行调查，提高常规ZIKV监测。方法爆发调查在患者联系人，发热病例和孕妇的患者案例中以3公里半径进行。常规监测得到增强，包括来自Rajasthan的各个地区的样本。通过实时PCR试验和CDC Trioplex试剂盒检测血清和尿液样品中ZIKV的存在。使用下一代测序方法对几个基因组分析进行测序很少有ZIKV阳性样品。结果爆发调查153/2043（7.48％）患病呈呈阳性：1/153（0.65％）在发热病例中90/153（58.8％），62/153（40.5％）在怀孕的女性中。在常规监测中，6/4722（0.12％）血清样品是ZIKV阳性。患者的MAJORITY患者患有温和的症状和症状，没有看到微微疫苗和Guillain-Barre综合征，25（40.3％）怀孕女性送健康婴儿，四个（6.4％）报告的堕胎和三（4.8％）宫内死亡，一（1.6％）儿童具有结直肠畸形，在诞生几天后死亡。 ZIKV被发现属于亚洲血统，未发现与增强的神经毒力和动物模型中的传播相关的突变。结论ZIKV对属于亚洲血统的印度内源性。 ZIKV的疾病概况是轻度的。在ZIKV阳性母亲出生的婴儿中没有观察到主要的异常;但是，需要长期跟进这些儿童。需要扩大印度病毒学实验室网络的监视，以进行早期检测和控制。概述Zika病毒感染因亚洲血型疾病而内源性，没有看到微微畸形或泪迹综合征，但需要随访的儿童，在该国需要加强ZIKV的监测。

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