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首页> 外文期刊>Journal of International Medical Research >Association of melatonin receptor 1 B gene (rs10830963 and rs9192552) polymorph?sm with adolescent obesity and related comorbidities in Turkey
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Association of melatonin receptor 1 B gene (rs10830963 and rs9192552) polymorph?sm with adolescent obesity and related comorbidities in Turkey

机译：<斜视>褪黑激素受体1b 基因（Rs10830963和Rs9192552）多晶型物与土耳其青少年肥胖症和相关合并症

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Objective To examine the role of rs10830963 and rs8192552 polymorphisms in melatonin receptor 1 B (MTNR1B) gene on the development of obesity and related comorbidities among adolescents in South-Eastern Turkey. Methods The present study included 200 unrelated adolescents (100 obese, 100 normal weight). The rs8192552 and rs10830963 polymorphisms in the MTNR1B gene were genotyped using a PCR SNaPshot assay. Results No statistically significant association was observed between MTNR1B gene rs8192552/rs10830963 polymorphisms and adolescent obesity. In adolescents with an rs8192552 E allele, homeostasis model assessment for insulin resistance (IR) level was lower and IR was less common. In morbidly obese adolescents with an rs8192552 E allele, total cholesterol level was lower. In obese adolescents with metabolic syndrome, plasma fasting glucose level was higher in rs10830963G allele carriers. In obese girls, body weight was lower in those with a rs10830963 C allele, whereas in obese boys, body weight and waist circumference were higher in those with a rs10830963 C allele. Conclusions The MTNR1B gene was not confirmed as an obesity susceptibility gene in adolescents. However, an association between the MTNR1B gene and IR/hypercholesterolemia/metabolic syndrome was observed in obese adolescents. A sex-specific effect on obesity was also identified.
机译：目的探讨Rs10830963和RS8192552多态性在褪黑激素受体1b（MTNR1B）基因上的作用对土耳其东南部青少年肥胖症及相关合并症的发展。方法本研究包括200个不相关的青少年（100肥胖，100个正常重量）。使用PCR快照测定，MTNR1B基因的RS8192552和RS10830963多态性进行基因分型。结果在MTNR1B基因RS8192552 / RS10830963多态性和青少年肥胖之间没有观察到统计学上显着的关联。在具有RS8192552 e等位基因的青少年中，稳态模型评估胰岛素抵抗（IR）水平较低，红外不太常见。在病态肥胖的青少年患有RS8192552 E等位基因，总胆固醇水平较低。在肥胖的青少年具有代谢综合征，血浆禁食葡萄糖水平较高，等位基因载体均高于载体。在肥胖的女孩中，体重在患有10830963克拉斯的等位基因中较低，而在肥胖的男孩中，体重和腰围的腰围较高，含有RS10830963 C等位基因。结论未确认MTNR1B基因作为青少年肥胖敏感性基因。然而，在肥胖的青少年观察到MTNR1B基因和IR /超胆固醇血症/代谢综合征之间的关联。还确定了对肥胖的性别特异性影响。

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