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首页> 外文期刊>Journal of International Medical Research >Tissue regeneration: an overview from stem cells to micrografts
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Tissue regeneration: an overview from stem cells to micrografts

机译：组织再生：从干细胞到微移植物的概述

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Regenerative medicine represents a major challenge for the scientific community. The choice of the biological sources used, such as stem cells and grafts, is crucial. Stem cell therapy is mainly related to the use of mesenchymal stem cells; however, clinical trials are still needed to investigate their safety. The micrografting technique was conceived by Cicero Parker Meek in 1958. It is based on the principle that by increasing the superficial area of skin grafts and reducing the size of its particles, it is possible to cover an area larger than the original donor site. Stem cells are pluripotent cells that have the capacity to differentiate into all cell types and are self-renewing, whereas micrografts derive from a small fragment of an autologous tissue and exhibit limited differentiative potential compared with stem cells. Therefore, stem cells and micrografts cannot be considered equivalent, although in some cases they exhibit similar regenerative potential, which is the focus of this review. Last, stem cell therapies remain limited because of complex and costly processes, making them not very feasible in clinical practice, whereas obtaining micrografts is generally a one-step procedure that does not require any advanced tissue manipulation.
机译：再生医学是科学界的重大挑战。选择的生物源，例如干细胞和移植物，是至关重要的。干细胞疗法主要与间充质干细胞的使用有关;然而，仍然需要临床试验来调查其安全性。由西科罗帕克温顺于1958年构思了微耕种技术。基于原理，通过增加皮肤移植物的浅表面积并减小其颗粒的尺寸，可以覆盖大于原始供体部位的面积。干细胞是具有分化成所有细胞类型并且自更新的能力的多能细胞，而微移植物从自体组织的小片段中衍生，并且与干细胞相比表现出有限的差异潜力。因此，干细胞和微血管不能被认为是等同的，尽管在某些情况下，它们表现出类似的再生潜力，这是本综述的重点。最后，由于复杂和昂贵的过程，干细胞疗法保持有限，使得它们在临床实践中不可行，而获得微血管通常是一种不需要任何先进组织操纵的一步法。

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