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首页> 外文期刊>Journal of International Medical Research >Pooled analysis of the efficacy and safety of adjunctive alpha-blocker therapy before ureteroscopy in the management of ureteral stones
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Pooled analysis of the efficacy and safety of adjunctive alpha-blocker therapy before ureteroscopy in the management of ureteral stones

机译：助长α-嵌体治疗在输尿管镜中疗效和安全性的疗效分析

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Objective To evaluate the efficacy and safety of adjunctive alpha-blocker therapy before ureteroscopy in the management of ureteral stones. Methods The databases MEDLINE ~(?), EMBASE and The Cochrane Controlled Trail Register of Controlled Trials were searched between January 1980 and June 2019 to identify randomized controlled trials (RCTs) that referred to the use of alpha-blockers as adjunctive therapy before ureteroscopy for the treatment of ureteral stones. Odds ratios (ORs) with 95% confidence intervals (CIs) were used for dichotomous outcomes; and mean difference (MD) with 95% CIs were used to report continuous outcomes. Results The analysis included five RCTs with a total of 557 patients. Compared with placebo, patients that received adjunctive alpha-blockers had significantly higher successful access to the stone (OR 5.44; 95% CI 2.99, 9.88), a significantly higher stone-free rate at the end of week 4 (OR 3.75; 95% CI 2.20, 6.39), significantly less requirement for balloon dilatation (OR 0.26; 95% CI 0.15, 0.44) and a significantly lower risk of complications (OR 0.25; 95% CI 0.15, 0.42). There was no significant difference in the operation time between the two groups (MD –3.33; 95% CI –7.03, 0.37). Conclusions Adjunctive alpha-blocker therapy administered before ureteroscopy was effective in the management of ureteral stones with a lower risk of complications than placebo treatment.
机译：目的评价辅助α-嵌体治疗在输尿管镜中的疗效和安全性。方法在2018年1月1980年1月和2019年6月期间检测数据库和Cochrane受控试验的Cochrane受控路径登记册，以确定在输尿管镜检查前将α-Delpleters作为辅助治疗的随机对照试验（RCT）。治疗输尿管石。具有95％置信区间（CIS）的差距（或）用于二分法结果;和平均差异（MD）用95％CIS用于报告连续结果。结果分析包括五个RCT，共有557名患者。与安慰剂相比，接受辅助α-阻滞剂的患者的患者可以逐步进入石头（或5.44; 95％CI 2.99,9.88），在第4周结束时具有明显更高的石材速率（或3.75; 95％ CI 2.20,6.39），对球囊扩张的要求显着较低（或0.26; 95％CI 0.15,0.44），并显着降低并发症风险（或0.25; 95％CI 0.15,0.42）。两组之间的操作时间没有显着差异（MD -3.33; 95％CI -7.03,0.37）。结论在输尿管镜检查前施用的辅助α-嵌体治疗在输尿管结石的管理中有效，其具有比安慰剂治疗的不良风险较低。

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