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首页> 外文期刊>Journal of International Medical Research >Polygala fallax Hemsl combined with compound Sanqi granules relieves glomerulonephritis by regulating proliferation and apoptosis of glomerular mesangial cells
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Polygala fallax Hemsl combined with compound Sanqi granules relieves glomerulonephritis by regulating proliferation and apoptosis of glomerular mesangial cells

机译：<斜视>聚集属proalax Hemsl与复合三q颗粒结合通过调节肾小球乳腺细胞的增殖和凋亡来减轻肾小球肾炎

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Objectives Glomerulonephritis is a serious kidney disease that can induce end-stage renal failure. The aberrant proliferation of mesangial cells is a cause of glomerulonephritis. Traditional Chinese medicines, such as Astragalus and Salvia miltrorrhiza , play important roles in the treatment of kidney-related diseases. However, the effects of a combination of Astragalus and S. miltrorrhiza -containing traditional Chinese medicines ( Polygala fallax Hemsl and compound Sanqi granules) on glomerulonephritis are unclear. Methods HRM cells (human mesangial cells) were stimulated with lipopolysaccharide to simulate glomerulonephritis. Separately, compound Sanqi granules and P. fallax Hemsl were administered to nude mice in various combinations. Serum was collected from the treated mice and added to HRM cells; the proliferation and apoptosis characteristics of the cells were assessed. Results The proliferation of HRM cells was inhibited after exposure to serum from treated mice. Exposure to serum from treated mice moderately induced apoptosis of HRM cells and lowered the expression levels of TNF-α, IL-1β, and IL-6. Conclusions Combination treatment with compound Sanqi granules and P. fallax Hemsl exerts a therapeutic effect on glomerulonephritis by inhibiting the proliferation of mesangial cells, while inducing apoptosis in those cells.
机译：目标肾小球肾炎是一种严重的肾脏疾病，可诱导终末期肾功能衰竭。 Mesangial细胞的异常增殖是肾小球肾炎的原因。中药，如黄芪和丹参米尔罗丘，在肾脏相关疾病的治疗中起重要作用。然而，黄芪和S.米尔鲁拉氏杆菌组合的影响 - 含有中药（Polygala Fallax Hemsl和化合物Sanqi颗粒）对肾小球肾炎的影响尚不清楚。方法用脂多糖刺激HRM细胞（人体乳腺细胞）以模拟肾小球肾炎。另外，将化合物Sanqi颗粒和P.Fallax Hemsl以各种组合施用于裸鼠。从处理过的小鼠中收集血清并加入到HRM细胞中;评估细胞的增殖和凋亡特征。结果从处理过的小鼠接触血清后抑制了HRM细胞的增殖。暴露于受处理的小鼠的血清中度诱导的HRM细胞凋亡，降低了TNF-α，IL-1β和IL-6的表达水平。结论通过抑制乳房细胞的增殖，在诱导细胞诱导细胞凋亡的同时对肾小球肾炎的组合治疗和P.Supax Hemsl对肾小球肾炎的组合治疗对肾小球肾炎进行治疗作用。

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