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首页> 外文期刊>Journal of International Medical Research >Autophagy-related long non-coding RNA signature for ovarian cancer
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Autophagy-related long non-coding RNA signature for ovarian cancer

机译：与卵巢癌的自噬相关的长非编码RNA签名

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Objective Ovarian cancer (OC) affects nearly 22,000 women annually in the United States and ranks fifth in cancer deaths, largely because of being diagnosed at an advanced stage. Autophagy is the cellular process of self-degrading damaged or degenerate proteins and organelles. Long non-coding RNAs (lncRNAs) are a group of RNA molecules whose transcripts are greater than 200 nt but are not translated into proteins. However, just a small number of autophagy-related lncRNAs have been explored in depth. Methods We used RNA sequencing data from The Cancer Genome Atlas (TCGA) and autophagy datasets to identify dysfunctional autophagy-related lncRNAs and provide potential useful biomarkers for OC diagnosis and prognosis. Results Seventeen differentially expressed lncRNAs (AC010186.3, AC006001.2, LBX2-AS1, SNHG17, AC011445.1, AC083880.1, MIR193BHG, AC025259.3, HCG14, AC007114.1, AC108673.2, USP30-AS1, AC010336.5, LINC01132, AC006333.2, LINC00665 and AC027348.1) were selected as independent prognostic factors for OC patients. Functional annotation of the data was performed through gene set enrichment analysis (GSEA). The results suggested that the high-risk group was mainly enriched in specific tumor-related and metabolism pathways. Conclusion Based on the online databases, we identified novel autophagy-related lncRNAs for the prognosis of ovarian cancer.
机译：目标卵巢癌（OC）每年在美国影响近22,000名女性，并在癌症死亡中排名第五，主要是因为被诊断出在高级阶段。自噬是自我降解受损或简并蛋白质和细胞器的细胞过程。长期非编码RNA（LNCRNA）是一组RNA分子，其转录物大于200nt但不翻译成蛋白质。但是，只有少量的自噬相关的LNCRNA被深入探讨。方法使用来自癌症基因组Atlas（TCGA）和自噬数据集的RNA测序数据，以鉴定与功能障碍自噬相关的LNCRNA，并为OC诊断和预后提供潜在的有用生物标志物。结果17个差异表达的LNCRNA（AC010186.3，AC006001.2，LBX2-AS1，SNHG17，AC011445.1，AC083880.1，MIR193BHG，AC025259.3，HCG14，AC007114.1，AC108673.2，USP30-AS1，AC010336。 5，LINC01132，AC006333.2，LINC00665和AC027348.1被选为OC患者的独立预后因素。通过基因设定富集分析（GSEA）进行数据的功能注释。结果表明，高风险群主要富含特异性肿瘤相关和新陈代谢途径。结论基于在线数据库，我们确定了新型自噬相关的LNCRNA，用于卵巢癌预后。

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