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首页> 外文期刊>Journal of International Medical Research >Polymorphism rs6478109 in the TNFSF15 gene contributes to the susceptibility to Crohn’s disease but not ulcerative colitis: a meta-analysis
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Polymorphism rs6478109 in the TNFSF15 gene contributes to the susceptibility to Crohn’s disease but not ulcerative colitis: a meta-analysis

机译：<斜视> TNFSF15 基因中的多态性RS6478109有助于对克罗恩病的易感性而不是溃疡性结肠炎：荟萃分析

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Objective Polymorphisms in the tumor necrosis factor superfamily 15 ( TNFSF15 ) gene contribute to susceptibility to inflammatory bowel disease (IBD). However, associations between TNFSF15 rs6478109, rs7869487, and rs7865494 polymorphisms and IBD remain unclear. Methods Eligible articles were retrieved from the PubMed, EMBASE, Web of Science, and CNKI databases through 20 March 2020. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the relationships of TNFSF15 polymorphisms with IBD susceptibility. Results Under the recessive model, TNFSF15 rs6478109 was associated with IBD risk (OR?=?0.56; 95% CI: 0.35, 0.92). Stratification analyses based on the type of disease—Crohn’s disease (CD) or ulcerative colitis (UC)—revealed a significant association under the allelic and recessive models between TNFSF15 rs6478109 and CD (allelic model: OR?=?0.84, 95% CI: 0.71, 0.99; recessive model: OR?=?0.44, 95% CI: 0.22, 0.87) but not UC. Stratification by ethnicity indicated a significantly decreased risk of IBD in Asian populations with TNFSF15 rs6478109 under the recessive model (OR?=?0.56, 95% CI: 0.35, 0.92). Conclusions Our meta-analysis suggested that under the allelic and recessive models, the TNFSF15 rs6478109 polymorphism was likely protective for CD but not UC in the Asian population.
机译：肿瘤坏死因子超家族15（TNFSF15）基因的客观多态性有助于炎症性肠病（IBD）的易感性。然而，TNFSF15 RS6478109，RS7869487和RS7865494多态性和IBD之间的关联仍不清楚。方法从2020年3月20日从PubMed，Embase，Science，CNKI数据库中检索符合条件的文章。汇集了具有95％置信区间（CIS）的汇集的差距（或者）以评估TNFSF15多态性与IBD易感性的关系。结果在隐性模型下，TNFSF15 RS6478109与IBD风险有关（或？= 0.56; 95％CI：0.35,0.92）。基于疾病-Crohn疾病（CD）或溃疡性结肠炎（UC）的分层分析 - 在TNFSF15 RS6478109和CD之间的等位基因和隐性模型下进行了重要关联（等位基因型：或？=？0.84,95％CI： 0.71,0.99;隐性模型：或？=？= 0.44,95％CI：0.22,0.87）但不是UC。民族的分层表明，在隐性模型下的TNFSF15 RS6478109（或？= 0.56,95％CI：0.35,0.92），在亚洲群体中具有显着降低的亚洲人口风险。结论我们的META分析表明，在等位基因和隐性模型下，TNFSF15 RS6478109多态性可能对CD但不是UC在亚洲人口中的保护性。

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