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首页> 外文期刊>Journal of International Medical Research >Association between miR-492 rs2289030 G&C and susceptibility to Hirschsprung disease in southern Chinese children
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Association between miR-492 rs2289030 G&C and susceptibility to Hirschsprung disease in southern Chinese children

机译：<斜视> miR-492之间的关联 rs2289030 g＆ c和南方南方儿童Hirschsprung病的易感性

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Objective Hirschsprung disease (HSCR) originates from disruption of normal neural crest cell migration, differentiation, and proliferation during the fifth to eighth weeks of gestation. This results in the absence of intestinal ganglion cells in the distal intestinal tract. However, genetic variations affecting embryonic development of intestinal ganglion cells are unclear. Therefore, this study aimed to investigated the potential value of miR-492 rs2289030 G&C as a marker of susceptibility to HSCR Methods In this case–control study in southern Chinese children, we collected samples from 1473 controls and 1470 patients with HSCR. TaqMan genotyping of miR-492 rs2289030 G&C was performed by real-time fluorescent quantitative polymerase chain reaction. Results Multivariate logistic regression analysis showed that there was no significant association between the presence of the miR-492 rs2289030 G&C polymorphism and susceptibility to HSCR by evaluating the values of pooled odds ratios and 95% confidence intervals. Similarly, among different HSCR subtypes, rs2289030 G&C was also not associated with HSCR in hierarchical analysis. Conclusions Our results suggest that the miR-492 rs2289030 G&C polymorphism is not associated with susceptibility to HSCR in southern Chinese children. These results need to be further confirmed by investigating a more diverse ethnic population of patients with HSCR.
机译：目的Hirschsprung疾病（HSCR）起源于妊娠第五周至第五周的正常神经嵴细胞迁移，分化和增殖的破坏。这导致在远端肠道中没有肠神经节细胞。然而，影响肠神经节细胞胚胎发育的遗传变异尚不清楚。因此，本研究旨在调查MIR-492卢比的潜在价值，如南方南方儿童对照研究中对HSCR方法的易感性的标志物，我们从1473次对照组和1470例HSCR患者收集样品。 MIR-492 RS2289030 G＆GT; C的Taqman基因分型通过实时荧光定量聚合酶链反应进行。结果多变量逻辑回归分析表明，通过评估汇集的大量比率和95％置信区间的价值，MIR-492 RS2289030 G＆GT的存在与HSCR的易感性之间没有显着关联。类似地，在不同的HSCR亚型中，RS2289030 g＆ c也没有与分级分析中的HSCR相关联。结论我们的结果表明MIR-492 RS2289030 G＆GT; C多态性与南方南方儿童的HSCR易感性无关。通过调查HSCR患者更多样化的族裔人群，需要进一步证实这些结果。

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