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首页> 外文期刊>Journal of International Medical Research >Serum apolipoprotein A-II and alpha-2-antiplasmin levels in midtrimester can be used as predictors of preterm delivery
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Serum apolipoprotein A-II and alpha-2-antiplasmin levels in midtrimester can be used as predictors of preterm delivery

机译：中大使中的血清载脂蛋白A-II和α-2-抗蛋白水平可用作早产输送的预测因子

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Objective To identify serum protein markers in midtrimester that predict preterm delivery. Methods A retrospective case–control study randomly selected patients that experienced spontaneous preterm birth and healthy control patients that experienced a normal delivery at term. A proteomic analysis was undertaken using the data-independent acquisition method. Results A total of 30 singleton pregnant women were randomly selected from 12?800 pregnant women: 15 women had a spontaneous preterm birth (group Y) and 15 age- and body mass index-matched women gave birth at term (group D). All of the patients provided serum at 15–20 weeks of gestation. A total of 39 differentially expressed proteins were identified. Compared with group D, 24 proteins were upregulated and 15 were downregulated in the preterm group Y. Using Kyoto Encyclopedia of Genes and Genomes pathway enrichment, the 24 upregulated proteins were significantly enriched in the complement and coagulation cascade pathways. Search Tool for the Retrieval of Interacting Genes Furthermore (STRING) analysis showed that apolipoprotein A-II (apoA-II) and alpha-2-antiplasmin (α2-AP), two upregulated proteins, were key nodes in the STRING protein–protein network. Conclusions These findings suggest that apoA-II and α2-AP might be new markers for predicting preterm delivery in the midtrimester.
机译：目的鉴定预测早产的中期脑中血清蛋白标记物。方法采用回顾性案例对照研究，随机选择经历过正常递送的自发早产儿的患者。使用独立于数据的采集方法进行蛋白质组学分析。结果共有30名单身孕妇从12岁孕妇中随机选中：15名孕妇：15名女性具有自发早产（组Y）和15岁和体重指数匹配的女性，术语（d组d）生育。所有患者在妊娠的15-20周内提供血清。鉴定了总共39个差异表达的蛋白质。与D组相比，上调24个蛋白质，在早产群中下调15例。使用京都基因和基因组途径富集，在补体和凝血级联途径中显着富集24个上调的蛋白质。用于检索的相互作用基因的搜索工具进一步（串）分析表明，载脂蛋白A-II（APOA-II）和α-2-抗蛋白（α2-AP），两个上调蛋白质是串蛋白质网络中的关键节点。结论这些研究结果表明，APOA-II和α2-AP可能是用于预测在中期大使中的早产的新标记。

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