MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer

Lin-zhu Yang; Chang-cheng Lei; Yun-ping Zhao; Hong-wen Sun; Qing-he Yu; En-Ji Yang; Xi Zhan

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MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer

机译：MicroRNA-34C-3P靶抑制NOTCH1抑制了非小细胞肺癌的化学敏感性和转移

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Background Chemotherapy is the standard treatment for non-small cell lung cancer (NSCLC). However, chemoresistance frequently occurs, making the treatment of NSCLC more difficult. Method We combined clinical and experimental studies to establish the role of microRNA (miR)-34c in NSCLC metastasis and chemoresistance. Results MiR-34c expression was significantly decreased in patients with NSCLC who showed a poor chemoresponse and metastasis. Overexpression of miR-34c sensitized NSCLC cells to paclitaxel and cisplatin both in vitro and in vivo . Furthermore, we found that NOTCH1 was target of miR-34c in NSCLC cells and played a key role in the effects of miR-34c on NSCLC. Conclusion NSCLC metastasis and chemoresistance are suppressed though the miR-34c/NOTCH1 axis. MiR-34c has important implications in the development of therapeutic strategies for metastasis and chemoresistance in NSCLC.

机译：背景技术化疗是非小细胞肺癌（NSCLC）的标准处理。然而，经常发生化学性，使NSCLC的处理更加困难。方法组合临床和实验研究，建立MicroRNA（MIR）-34C在NSCLC转移和化学抑制中的作用。结果NSCLC患者显示出差的化学响应和转移的患者MIR-34C表达显着降低。 MiR-34C的过表达在体外和体内敏感的NMSCLC细胞对紫杉醇和顺铂的过度表达。此外，我们发现Notch1是NSCLC细胞中miR-34c的靶标，并在MIR-34c对NSCLC的影响中发挥了关键作用。结论MIR-34C / NOTCH1轴抑制了NSCLC转移和化学抑制。 MIR-34C对NSCLC中的转移和化学性的治疗策略具有重要意义。

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《Journal of International Medical Research》 |2020年第3期|共11页
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Lin-zhu Yang; Chang-cheng Lei; Yun-ping Zhao; Hong-wen Sun; Qing-he Yu; En-Ji Yang; Xi Zhan;
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Non-small cell lung cancermiR-34cmetastasisNOTCH1chemoresistancegene expression;

机译：非小细胞肺癌瘤虫-34CMETASTASNOTCH1筛选术;

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1. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression [J] . Michael G. Edwards, Katherine Vandervest, John Arcaroli, Biology Open . 2013,第7期

机译：hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中的抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶点）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用
2. Inhibition of histamine receptor H3 suppresses the growth and metastasis of human non-small cell lung cancer cells via inhibiting PI3K/Akt/mTOR and MEK/ERK signaling pathways and blocking EMT [J] . Yan-yan Zhao, Shi-rong Zhang, Jing Jia, 中国药理学报：英文版 . 2021,第008期

机译：组胺受体H3的抑制通过抑制PI3K / AKT / MTOR和MEK / ERK信号通路并阻止EMT来抑制人非小细胞肺癌细胞的生长和转移
3. Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer [J] . The international journal of biochemistry and cell biology . 2020,第期

机译：细胞粘附分子4通过抑制非小细胞肺癌中的AKT信号通路来抑制细胞生长和转移
4. bcl-2 anti-apoptotic oncoprotein suppresses angiogenesis in non-small cell lung cancer: implications in resistance to photodynamic treatment? [C] . Author(s): M.I. Koukourakis Univ. Hospital of Iraklion (Greece) and Saint Savvas Hospital Iraklion Greece, A.Giatromanolaki Univ. Hospital of Iraklion (Greece) and Saint Savvas Hospital Iraklion Greece, J.Skarlatos Univ. Hospital of Iraklion (Greece) and Saint Savvas Hospital Iraklion Greece, GR-I international conference on new Laser technologies and applications . 1997

机译：bcl-2抗凋亡癌蛋白抑制非小细胞肺癌的血管生成：对光动力治疗的抵抗性有何影响？
5. Crippling Rapid Evolution of Metastasis and Drug Resistance in A549 Non-Small Cell Lung Cancer Cells with the Clinically Relevant HSP90 Inhibitor AUY922 [D] . Bacon, Nickolas. 2021

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6. MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer [O] . Lin-zhu Yang, Chang-cheng Lei, Yun-ping Zhao, 2020

机译：MicroRNA-34c-3p靶标抑制NOTCH1抑制非小细胞肺癌的化学敏感性和转移
7. Downregulation of miR-522 suppresses proliferation and metastasis of non-small cell lung cancer cells by directly targeting DENN/MADD domain containing 2D [O] . Tianze Zhang, Yingying Hu, Jin Ju, 2016

机译：miR-522的下调通过直接靶向含有2D的Denn / Madd结构域来抑制非小细胞肺癌细胞的增殖和转移

MicroRNA-34c-3p target inhibiting NOTCH1 suppresses chemosensitivity and metastasis of non-small cell lung cancer

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