...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of International Medical Research >Challenges in early identification of causes and treatment of cholestasis in patients with hyperthyroidism: a case report and literature review
【24h】

Challenges in early identification of causes and treatment of cholestasis in patients with hyperthyroidism: a case report and literature review

机译：甲状腺功能亢进患者早期鉴定胆囊的早期鉴定和治疗挑战：案例报告和文献综述

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Early identification of the causes of cholestasis is important for appropriate management of patients with hyperthyroidism. We report a patient who had hyperthyroidism and severe cholestasis after methimazole (MMI) treatment. The patient was diagnosed as having MMI-induced cholestatic hepatitis. Treatment with MMI was stopped at admission to hospital. However, his serum total bilirubin (TBil) level rose from 410.5?μmol/L to 519.9 μmol/L and prothrombin time activity (PTA) dropped from 81.0% to 52.2% in 10 days. To prevent further deterioration of his liver function, plasma exchange was performed three times, and dexamethasone (10?mg, intravenously) was used each time. His PTA rose to 101% and his TBil continued to increase to 669.8?μmol/L after plasma exchange. He was subsequently diagnosed as having thyrotoxicosis-induced cholestasis and treated with radioactive iodine (380 MBq) 2 weeks after admission. His hyperthyroidism was significantly relieved, but the TBil level further increased to 776.8?μmol/L. Three weeks after admission, oral prednisone (30 mg/day) was used in this patient. Subsequently, his TBil levels gradually decreased and his liver function almost normalized within 3 months. We discuss the literature on cholestasis in the context of hyperthyroidism.
机译：早期鉴定胆汁淤积的原因对于适当的甲状腺功能亢进患者的治疗是重要的。我们报告了甲基唑（MMI）治疗后患有甲状腺功能亢进和严重胆汁淤积的患者。患者被诊断为具有MMI诱导的胆汁淤积性肝炎。含有MMI的治疗在入院时停止了医院。然而，他的血清总胆红素（Tbil）水平从410.5？μmol/ l至519.9μmol/ L和凝血酶原时间活性（PTA）在10天内从81.0％降至52.2％。为了防止他的肝功能进一步恶化，每次使用血浆交换三次，并且每次使用地塞米松（静脉内，静脉内）。他的PTA上升至101％，他的比尔在等离子交换后继续增加到669.8？μmol/ l。随后被诊断为具有甲状腺毒症诱导的胆汁淤积，并在入院后2周使用放射性碘（380 MBQ）治疗。他的甲状腺功能亢进症得到了显着的缓解，但TBIL水平进一步增加到776.8？μmol/ L.入院后三周，本患者使用口服泼尼松（30mg /天）。随后，他的Tbil水平逐渐减少，他的肝功能几乎在3个月内归一成。我们在甲状腺功能亢进的背景下讨论胆汁淤积的文献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号