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首页> 外文期刊>Journal of Investigative Medicine High Impact Case Reports >Scleroderma Renal Crisis in Mixed Connective Tissue Disease With Full Renal Recovery Within 3 Months: A Case Report With Expanding Treatment Modalities to Treat Each Clinical Sign as an Independent Entity
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Scleroderma Renal Crisis in Mixed Connective Tissue Disease With Full Renal Recovery Within 3 Months: A Case Report With Expanding Treatment Modalities to Treat Each Clinical Sign as an Independent Entity

机译：硬皮病在混合结缔组织疾病中的肾脏危机在3个月内具有完全肾复苏：一个案例报告，扩大治疗方式，将每个临床符号视为独立实体

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摘要

Mixed connective tissue disease (MCTD) is a rheumatologic overlap syndrome that can present with symptoms of systemic lupus erythematous, scleroderma, and polymyositis. A severe but rare complication that can occur in MCTD is scleroderma renal crisis. With multiple poor prognostic indicators, the renal outcome is usually poor. The clinical and histological picture is one of a thrombotic microangiopathy. Clinical suspicion has to be high for additional thrombotic or autoimmune processes coexisting due to associated morbidity. In this article, we report a rare case of scleroderma renal crisis in a patient with MCTD who we treated with plasma exchange for clinical suspicion for an underlying thrombotic thrombocytopenia and mycophenolate mofetil for MCTD. The patient had multiple poor prognostic indicators yet made a full renal recovery in less than 3 months.
机译：混合结缔组织疾病（MCTD）是一种风湿性重叠综合征，可以存在于系统性红斑狼疮，硬皮病和多发性肌炎的症状。在MCTD中可能发生的严重但罕见的并发症是硬皮病肾危机。具有多种差的预后指标，肾果糖通常差。临床和组织学图片是一种血栓形成微动病变之一。临床怀疑对于额外的血栓或自身免疫过程具有很高的血栓性或自身免疫过程由于相关的发病率而共存。在本文中，我们在患有MCTD的患者中报告了罕见的患者患有血浆交换治疗的患者临床怀疑，用于MCTD的潜在血栓性血小板血细胞缺乏症和霉酚酸酯MOFETIL。患者有多种贫困预后指标，但在不到3个月的时间内进行了全肾复苏。

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