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首页> 外文期刊>Journal of King Saud University >Study on the role of flavonoids derived extract from seed residues of hippophae rhamnoides on high-fat diet induced obese mice
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Study on the role of flavonoids derived extract from seed residues of hippophae rhamnoides on high-fat diet induced obese mice

机译：黄酮类药物衍生提取物从海马犀牛种子残留对高脂饮食诱导肥胖小鼠的作用

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The objective of the paper was to explore the active mechanism underlying the role of flavonoids, which were derived from seed residues of hippophae rhamnoides (Flavonoids from the Seeds of H. rhamnoides L., FSH), in obesity. A total of 50 SPF healthy male C57BL/6 mice were selected and divided into 5 groups (with 10 mice in each group), i.e., the normal control group, the high fat diet control group, the 100?mg/kg FSH group, the 300?mg/kg FSH group, and the rosiglitazone group. The basic biochemical indicators of the mice were detected, and the liver and white adipose tissue samples were collected, stained and analyzed via Western Blot to study the effects of flavonoids on obesity. In the experiment, rosiglitazone was used as a traditional weight-inhibiting drug and its efficacy was compared with that in the FSH groups. It was found that compared with that in the high-fat diet control group, the weight gain of obese mice administered with FSH was slowed, along with reduced levels of serum total cholesterol, plasma glucose, and liver fat accumulation. Meanwhile, it was also discovered that FSH could reduce the expression of PPARγ in liver and white adipose tissues, thus helping to reduce fat accumulation. It was proved that the flavonoids derived from seed residues of hippophae rhamnoides exerted an inhibitory effect on obesity to protect the liver.
机译：本文的目的是探讨黄酮类化合物作用的活性机制，这些机制是肥胖症中源自海皮酚菌毒素的种子残留物（来自H. rhamnoides L.，FSH的种子的黄酮类化合物）。选择共50个SPF健康雄性C57BL / 6小鼠并分为5组（每组10只小鼠），即正常对照组，高脂饮食对照组，100？Mg / Kg FSH组， 300？Mg / kg FSH组和罗格列酮组。检测到小鼠的基本生化指标，通过蛋白质印迹收集，染色和分析肝脏和白色脂肪组织样品，以研究黄酮类化对肥胖症的影响。在实验中，Rosiglitazone被用作传统的体重抑制药物，并且其疗效与FSH组中的疗效进行了比较。结果发现，与高脂饮食对照组的比较，肥胖小鼠的重量增益减缓，随着血清总胆固醇，血浆葡萄糖和肝脂肪积累的降低。同时，还发现FSH可以降低肝脏和白色脂肪组织中PPARγ的表达，从而有助于减少脂肪积累。证明，源自海皮菌毒素的种子残留物的类黄酮对肥胖施用抑制作用以保护肝脏。

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