• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of King Saud University >Anti-biofilm compound of 1, 4-diaza-2, 5-dioxo-3-isobutyl bicyclo[4.3.0]nonane from marine Nocardiopsis sp. DMS 2 (MH900226) against biofilm forming K. pneumoniae
【24h】

Anti-biofilm compound of 1, 4-diaza-2, 5-dioxo-3-isobutyl bicyclo[4.3.0]nonane from marine Nocardiopsis sp. DMS 2 (MH900226) against biofilm forming K. pneumoniae

机译：1,4- diaza-2,5-二氧基-3-异丁基双环[4.3.0]壬烷的抗生物膜化合物腹膜术 sp。 DMS 2（MH900226）对抗生物膜形成 k。肺炎

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, the 16S rRNA of the marine endophytic actinomycete was characterized and identified asNocardiopsis sp. strain DMS 2 (MH900226). Partial purification and spectroscopies data were interpreted and confirmed as 1, 4-diaza-2, 5-dioxo-3-isobutyl bicyclo[4.3.0]nonane. Anti-bacterial activity of the crude extract and partially purified compound were shown highest inhibition activity against biofilm formingK. pneumoniae. Minimum biofilm inhibition concentration of identified compound againstK. pneumoniaewas exhibited at the concentration of 300?μg/mL. Decreased metabolic activity and modified exopolysaccharide production of biofilm forming cells were observed at 350?μg/mL and 300?μg/mL concentration. At the same biofilm inhibition concentration, the intracellular architecture of the biofilm cells and extracellular shape modifications were clearly viewed by confocal laser scanning electron microscope and scanning electron microscope respectively. All thein-vitroinhibition results and microscopic images were strongly suggested that the identified compound was a potential anti-biofilm agent against testedK. pneumoniae.
机译：在该研究中，母猪内生菌肌瘤的16S rRNA表征并鉴定为asnocardiopsis sp。应变DMS 2（MH900226）。将部分纯化和光谱数据进行解释，并证实为1,4-DiaZa-2,5-二氧基-3-异丁基双环[4.3.0]壬烷。粗提物和部分纯化化合物的抗菌活性显示出对生物膜成形的最高抑制活性。肺炎。最低生物膜抑制鉴定的化合物逆。肺炎在300μg/ ml的浓度下展示。在350×μg/ ml和300μg/ ml浓度下观察到生物膜形成细胞的代谢活性降低和改性的外偶糖。在相同的生物膜抑制浓度下，分别通过共聚焦激光扫描电子显微镜和扫描电子显微镜清楚地观察生物膜细胞的细胞内架构和细胞外形修饰。强烈建议所鉴定的化合物是针对睾丸的潜在抗生物膜剂的所有蛋白 - 玻璃体抑制结果和微观图像。肺炎。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号