Methanol extract of <ce:italic>Artemisia brevifolia</ce:italic> as a curative agent against CCl <ce:inf loc='post'>4</ce:inf> induced nephrotoxicity in albino rats

Hira Ahsan; Muhammad Umar Ijaz; Asma Ashraf; Nazia Ehsan; Razia Noreen; Sara Zafar; Abdul Samad; K.A. AlGhanim; F. Al-Misned; N. Al-Mulahim; Z.A. Kaimkhani; Shahid Mahboob

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Methanol extract of Artemisia brevifolia as a curative agent against CCl 4 induced nephrotoxicity in albino rats

机译：壁式的甲醇提取物斜体>作为ccl的治疗剂 4 诱导白果大鼠的肾毒性

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Carbon tetrachloride (CCl4) is a Potential nephrotoxin that causes severe and prolonged chemical toxicity. Investigations have been accomplished on numerous species of genusArtemisia, but the plantArtemisia brevifoliahas hardly been used in this respect. The present study was considered to ascertain the effects of “Artemisia brevifoliaplant extract” against CCl4prompted nephrotoxicity in male albino rats. Forty-eight male albino rats were allocated into eight groups containing 6 rats in each. Group I was the control group. Group II was given dimethyl sulfoxide (DMSO) (1?ml/kg) orally. Group III was treated with dissolved CCl4in olive oil (1?ml/kg). Group IV was given CCl4?+?Silymarine. Group V and VI were administered withArtemisia brevifoliaextract (150 and 300?mg/kg respectively)?+?CCl4. Group VII and VIII were provided with only 150 and 300?mg/kg extract ofArtemisia brevifoliarespectively. Results displayed that CCl4administration significantly (p?

机译：四氯化碳（CCL4）是一种潜在的肾毒素，导致严重和长时间的化学毒性。在许多种类的血统血小毒症上已经完成了调查，但Plantartemisia Brevifoliahas几乎没有用于这方面。本研究被认为是确定“Artemisia Brevifoliapl萃取物”对雄性白化大鼠CCL4备注肾毒性的影响。将四十八只雄性白化大鼠分配到含有6只大鼠的八组。小组是对照组。 II族对二甲基亚砜（DMSO）（1×mL / kg）口服给予。将III组用溶解的CCL4IN橄榄油（1？mL / kg）处理。第IV族给予CCL4？+ +？Silymarine。 v和vi族和vi分别施用Brevifolia extract（分别为150和300μm≤kg）？+？CCl4。第VII组和VIII组仅为150和300？Mg / kg提取物的胃肠杆菌。结果显示CCL4Administration显着（P？<0.05）降低了抗氧化酶，如过氧化度酶（猫），过氧化物酶（POD），超氧化物歧化酶（SOD），谷胱甘肽（GSH），谷胱甘肽还原酶（GSR），谷胱甘肽-S-转移酶（GST），白蛋白，肌酐清除和彗星参数（头部长度，头部％），同时增加了硫碱尿酸反应性物质（TBARS），过氧化氢（H2O2），尿素，肌酐，胆管油，尿蛋白和彗星参数的水平（彗星，尾部长度，彗星长度，尾部，尾部百分比）。胃肠杆菌的给药Brevifoliasigationally（p？<0.05）改善了肾组织的组织病理学。结果揭示了对CCL4诱导的肾脏损伤的跖芽保护后果。

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《Journal of King Saud University》 |2020年第7期|共7页
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Hira Ahsan; Muhammad Umar Ijaz; Asma Ashraf; Nazia Ehsan; Razia Noreen; Sara Zafar; Abdul Samad; K.A. AlGhanim; F. Al-Misned; N. Al-Mulahim; Z.A. Kaimkhani; Shahid Mahboob;
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Carbon tetrachlorideNephrotoxicityArtemisia brevifoliaProtective effectsAntioxidant enzymes;

机译：碳四氯化钠毒毒性细胞胃部胃部胃部胃部毒性酶毒性酶;

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Methanol extract of Artemisia brevifolia as a curative agent against CCl 4 induced nephrotoxicity in albino rats

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