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首页> 外文期刊>Journal of Korean medical science. >High-Flow Nasal Cannula Oxygen Therapy Can Be Effective for Patients in Acute Hypoxemic Respiratory Failure with Hypercapnia: a Retrospective, Propensity Score-Matched Cohort Study
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High-Flow Nasal Cannula Oxygen Therapy Can Be Effective for Patients in Acute Hypoxemic Respiratory Failure with Hypercapnia: a Retrospective, Propensity Score-Matched Cohort Study

机译：高流量鼻腔套管氧疗法对于急性缺氧呼吸衰竭的患者可有效患有Hypercapnia：回顾性，倾向分数匹配队列队列研究

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Background Usually, high-flow nasal cannula (HFNC) therapy is indicated for de novo acute hypoxemic respiratory failure (AHRF). Although only a few researches have examined the effectiveness of HFNC therapy for respiratory failure with hypercapnia, this therapy is often performed under such conditions for various reasons. We investigated the effectiveness of HFNC therapy for AHRF patients with hypercapnia compared to those without hypercapnia. Methods All consecutive patients receiving HFNC therapy between January 2012 and June 2018 at a university hospital were enrolled and classified into nonhypercapnic and hypercapnic groups. We compared the outcomes of both groups and adjusted the outcomes with propensity score matching. Results A total of 862 patients were enrolled, of which 202 were included in the hypercapnic group. HFNC weaning success rates were higher, and intensive care unit (ICU) and hospital mortality was lower in the hypercapnic group than in the nonhypercapnic group (all P 0.05). However, no statistical differences in HFNC weaning success (adjusted P = 0.623, matched P = 0.593), ICU mortality (adjusted P = 0.463, matched P = 0.195), and hospital mortality (adjusted P = 0.602, matched P = 0.579) were noted from the propensity-adjusted and propensity-matched analyses. Additionally, in the propensity score-matched subgroup analysis (according to chronic lung diseases and causes of HFNC application), there was also no significant difference in outcomes between the two groups. Conclusion In AHRF with underlying conditions, HFNC therapy might be helpful for patients with hypercapnia. Large prospective and randomized controlled trials are required for firm conclusions.
机译：背景技术通常，为缺血呼吸呼吸衰竭（AHRF）表示高流量鼻腔套管（HFNC）治疗。虽然只有少数研究已经检查了HFNC治疗对呼吸衰竭的呼吸衰竭的有效性，但这种治疗通常在这些条件下进行，因为各种原因。我们研究了HFNC治疗对AHRF患者的HFNC治疗与Hypercapnia的HFNC患者相比，与没有血汗的血症。方法在大学医院1月至2018年1月至2018年6月间接受HFNC治疗的所有连续患者均注册并分类为非酒经许和高竞争团体。我们比较了两组的结果，并调整了倾向分数匹配的结果。结果共于862名患者注册了862名患者，其中202名包括在高碳酸群体中。 HFNC断奶成功率较高，高速群体群体的重症监护单位（ICU）和医院死亡率低于非金属菌群（所有P <0.05）。然而，HFNC断奶成功的统计学差异（调整后P = 0.623，匹配的P = 0.593），ICU死亡率（调整为P = 0.463，匹配的P = 0.195），以及医院死亡率（调整的P = 0.602，匹配P = 0.579）从倾向调整的和倾向匹配的分析中注意到。另外，在倾向得分匹配的亚组分析中（根据慢性肺病和HFNC应用的原因），两组之间也没有显着差异。结论在患有潜在条件的AHRF中，HFNC治疗可能对Hypercapnia的患者有所帮助。坚定的结论，需要大型前瞻性和随机对照试验。

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