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首页> 外文期刊>Journal of Neural Transplantation and Plasticity: Neural Plasticity >Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects
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Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects

机译：针刺结合间充质干细胞移植对脊髓损伤后神经恢复的影响及其方法：进展与前景

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摘要

Spinal cord injury (SCI) is a structural event with devastating consequences worldwide. Due to the limited intrinsic regenerative capacity of the spinal cord in adults, the neural restoration after SCI is difficult. Acupuncture is effective for SCI-induced neurologic deficits, and the potential mechanisms responsible for its effects involve neural protection by the inhibition of inflammation, oxidation, and apoptosis. Moreover, acupuncture promotes neural regeneration and axon sprouting by activating multiple cellular signal transduction pathways, such as the Wnt, Notch, and Rho/Rho kinase (ROCK) pathways. Several studies have demonstrated that the efficacy of combining acupuncture with mesenchymal stem cells (MSCs) transplantation is superior to either procedure alone. The advantage of the combined treatment is dependent on the ability of acupuncture to enhance the survival of MSCs, promote their differentiation into neurons, and facilitate targeted migration of MSCs to the spinal cord. Additionally, the differentiation of MSCs into neurons overcomes the problem of the shortage of endogenous neural stem cells (NSCs) in the acupuncture-treated SCI patients. Therefore, the combination of acupuncture and MSCs transplantation could become a novel and effective strategy for the treatment of SCI. Such a possibility needs to be verified by basic and clinical research.
机译：脊髓损伤（SCI）是一个结构事件，全世界具有破坏性后果。由于成人脊髓的内在再生能力有限，SCI后的神经修复难。针灸对SCI诱导的神经系统缺陷有效，负责其效果的潜在机制涉及通过抑制炎症，氧化和凋亡的神经保护。此外，通过激活多个细胞信号转导途径，例如Wnt，凹口和rhO / rhO激酶（岩）途径，促进神经再生和轴突发芽。几项研究表明，将针灸与间充质干细胞（MSCs）移植组合的疗效优于单独的方法。合并治疗的优点取决于针灸增强MSC的存活的能力，促进其分化为神经元，促进MSCs的靶向迁移到脊髓。另外，MSCs进入神经元的分化克服了针灸治疗的SCI患者中内源神经干细胞（NSCs）的短缺问题。因此，针灸和MSCs移植的组合可能成为治疗SCI的新颖有效策略。需要通过基本和临床研究验证这种可能性。

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