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Communication at the host-pathogen interface

机译：Host-Pathogen接口处的通信

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The oral cavity represents a finely balanced ecosystem in which a plethora of bacterial species lives in complex communities known as biofilms. To cohabitate efficiently, bacteria within these biofilms have evolved intricate systems of communication, such as quorum sensing, cooperation or competition, involving signaling, sharing of resources and/or metabolic activities. Dysbiosis can develop and lead to periodontitis, the most common human chronic inflammatory disease. Briefly, Streptococci, recognised as early colonisers, are followed by Fusobacterium nucleatum, known as a ‘bridging organism’. The latter interacts with multiple bacterial species, facilitating their adherence, leading to formation of a disease-associated biofilm. Specifically, bacteria of the “red complex” (Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola) and Aggregatibacter actinomycetemcomitans emerge to prominence within the periodontal pocket.While this aggregation of different species is well documented, ...
机译：口腔代表了一种细腻平衡的生态系统，其中血清的细菌物种生活在称为生物膜的复杂群体中。为了有效地同植，这些生物膜内的细菌已经进化了复杂的通信系统，例如法定传感，合作或竞争，涉及信号，资源分享和/或代谢活动。消化不良可以发展和导致牙周炎，最常见的人类慢性炎症疾病。简而言之，被认为是早期结肠剂的链球菌，其次是核酸杆菌，称为“桥接生物”。后者与多种细菌物种相互作用，促进其粘附，导致形成疾病相关的生物膜。具体而言，“红色复合物”的细菌（Porphyromonas Gingivalis，Tannerella连翘，Tannerella牙科菌）和聚合杆菌诱导术中出现在牙周口袋内的突出。当这种不同物种的聚集有很好的记录，......

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