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首页> 外文期刊>Journal of Oral Microbiology >Determination of MIC of amoxicillin among clinical strains of Aggregatibacter actinomycetemcomitans from various geographic regions endorse the continuous use of this drug for treatment of periodontitis
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Determination of MIC of amoxicillin among clinical strains of Aggregatibacter actinomycetemcomitans from various geographic regions endorse the continuous use of this drug for treatment of periodontitis

机译：各种地理区域临床疗法临床菌株临床菌株的麦克风素麦克风的测定始于使用该药物治疗牙周炎的持续使用

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Aim: The combination of amoxicillin and metronidazole is used in the treatment of Aggregatibacter actinomycetemcomitans (Aa)-associated periodontitis in some patients. Aa is innately susceptible to betalactam agents, but resistance or decreased susceptibility has been reported. Elucidation of the prevalence and mechanisms of resistance to betalactams in Aa is important in order to treat periodontitis patients with the most optimal antibiotic regimen.Method: 259 Aa strains were collected from patients with geographically diverse origin and serotyped with a multiplex PCR. Minimal inhibitory concentration (MIC) values were determined using the agar dilution method, with amoxicillin (range 0.00 mg/L to 8.00 mg/L) incorporated into 5 % blood agar plates with 20 mg/mL NAD. The plates were inoculated with 1 μL bacterial suspensions (104 CFU/ml), incubated in 5 % CO2 at 37 C°, and visually inspected after 24 and 48 hours. A MIC ≥ 4.00 mg/L was categorised as resistant, using EUCAST interpretative criteria...
机译：目的：Amoxicillin和甲硝唑的组合用于治疗聚集杆菌菌霉素（AA） - 在一些患者中的牙周炎。 AA天然易于贝酰胺酰胺剂，但据报道抗性或易感性降低。阐明患病患者患者患者对甲酸脱肌驼的抗病率和机制是重要的，以便治疗牙周炎患者最佳的抗生素裁员患者。方法：259 AA菌株从地理上多样的起源患者收集，并用多重PCR血清型。使用琼脂稀释法测定最小抑制浓度（MIC）值，其掺入具有20mg / ml NAD的5％血琼脂平板中的阿莫西林（0.00mg / L至8.00mg / L）。用1μL细菌悬浮液（104 CFU / mL）接种平板，在37℃下在5％CO 2中温育，并在24至48小时后视觉检查。 MIC≥4.00mg/ l分为抗性，使用EUCAST解释标准......

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