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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >Application of iChip to Grow “Uncultivable” Microorganisms and its Impact on Antibiotic Discovery
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Application of iChip to Grow “Uncultivable” Microorganisms and its Impact on Antibiotic Discovery

机译：ichip在抗生素发现中生长“植物”微生物的应用及其对抗生素发现的影响

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Antibiotics have revolutionized modern medicine, allowing significant progress in healthcare and improvement in life expectancy. Development of antibiotic resistance by pathogenic bacteria is a natural phenomenon; however, the rate of antibiotic resistance emergence is increasing at an alarming rate, due to indiscriminate use of antibiotics in healthcare, agriculture and even everyday products. Traditionally, antibiotic discovery has been conducted by screening extracts of microorganisms for antimicrobial activity. However, this conventional source has been over-used to such an extent that it poses the risk of “running out” of new antibiotics. Aiming to increase access to a greater diversity of microorganisms, a new cultivation method with an in situ approach called iChip has been designed. The iChip has already isolated many novel organisms, as well as Teixobactin, a novel antibiotic with significant potency against gram-positive bacteria. This article is open to POST-PUBLICATION REVIEW . Registered readers (see “For Readers”) may comment by clicking on on the issue’s contents page.
机译：抗生素已经彻底改变了现代医学，允许在医疗保健方面取得重大进展，并在预期寿命的改善。通过致病性细菌的抗生素抗性的发展是一种自然现象;然而，由于医疗保健，农业甚至日常产品中的抗生素滥用使用，抗生素抗性出现的速率是令人震惊的速度增加。传统上，通过筛选微生物提取物进行抗微生物活性的抗生素发现。然而，这种传统的来源已经过度使用，因此它构成了新抗生素“耗尽”的风险。旨在增加对微生物多样性的进入，设计了一种具有众所述方法的新型培养方法，称为Ichip。 ichip已经孤立了许多新的生物，以及一种新的抗生素，具有针对革兰氏阳性细菌的显着效力的新型抗生素。本文对发布后审查开放。注册读者（参见“对于读者”）可以通过单击“问题的内容”页面进行评论。

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