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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >Pharmacologic Activities? of 3’-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity
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Pharmacologic Activities? of 3’-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity

机译：药理学活动？ 3'-羟基替索尔：细胞毒性，抗氧化剂，抗脂肪发生，抗炎，组蛋白脱乙酰酶和SIRTUIN 1抑制活性

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Purpose : Delineate the selected pharmacodynamics of a naturally occurring stilbene 3’-Hydroxypterostilbene. Objective: Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology and pathophysiology. Methods : 3’-Hydroxypterostilbene was studied in in-vitro assays to identify possible bioactivity. Results: 3’-Hydroxypterostilbene demonstrated anti-oxidant, anti-inflammatory, cytotoxic, anti-adipogenic, histone deacetylase, and sirtuin-1 inhibitory activity. Conclusions: The importance of understanding individual stilbene pharmacologic activities were delineated. Small changes in chemical structure of stilbene compounds result in significant pharmacodynamic differences. This article is open to POST-PUBLICATION REVIEW . Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
机译：目的：描绘自然发生的斯蒂尔贝烯3'-羟基苯乙烯的所选药效学。目的：首次表征若干体外测定中的药效动力学生物活性，在心脏病，炎症，癌症和糖尿病病因和病理生理学中具有相关作用。方法：在体外测定中研究了3'-羟基替索替索，以确定可能的生物活性。结果：3'-羟基替替洛替者证明了抗氧化剂，抗炎，细胞毒性，抗脂肪发生，组蛋白脱乙酰酶，以及SIRTUIN-1抑制活性。结论：理解单个斯蒂尔比药理学活动的重要性划定了划定。芪化合物的化学结构的小变化导致显着的药效流体动力学差异。本文对发布后审查开放。注册读者（参见“对于读者”）可以通过单击“问题的内容”页面上的“摘要”来评论。

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