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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >Buoyancy-Generating Agents for Stomach-Specific Drug Delivery: An Overview with Special Emphasis on Floating Behavior
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Buoyancy-Generating Agents for Stomach-Specific Drug Delivery: An Overview with Special Emphasis on Floating Behavior

机译：用于胃特异性药物交付的浮力发电剂：概述特别强调浮动行为

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摘要

Gastric retentive drug delivery provides a promising technology exhibiting an extended gastric residence and a drug release independent of patient related variables. It is usually useful in improving local gastric treatment as well as overcoming drug-related problems .i.e. drugs having narrow absorption window, short half-life or low intestinal solubility. Buoyancy is considered one of the most promising approaches for gastro-retention of dosage forms. Floating drug delivery systems have a bulk density lower than gastric fluids and thus remain buoyant in the stomach causing an increase in gastric residence time. The buoyancy of these systems is attained by the aid of substances responsible to generate the low density. Various agents with different mechanisms were adopted either gas-generating agents, air entrapping swellable polymers, inherent low density substances, porous excipients, hollow/porous particles inducing preparation techniques or sublimating agents. Therefore, this review gives an exclusive descriptive classification of the different categories of these buoyancy-generating agents while representing the related research works. An overview is also conducted to describe relevant techniques assessing the floating behavior of such dosage forms either in vitro or in vivo. Finally, a collection representing FDA-approved floating pharmaceutical products is adopted with emphasis on the buoyancy-generating agent type used in each product. This article is open to POST-PUBLICATION REVIEW . Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
机译：胃保留药物递送提供了一种有希望的技术，其具有扩展的胃住宅和与患者相关变量无关的药物释放。它通常在改善局部胃部治疗以及克服毒品相关问题时。吸收窗的药物，半衰期短或低肠溶性。浮力被认为是胃保留剂型最有希望的方法之一。浮动药物递送系统的堆积密度低于胃液，因此在胃中保持升高，导致胃停留时间增加。这些系统的浮力通过负责产生低密度的物质而获得。采用具有不同机制的各种试剂，通过产生不同机制，空气诱捕可溶胀的聚合物，固有的低密度物质，多孔赋形剂，诱导制备技术或升华剂的中空/多孔颗粒。因此，本综述给出了这些浮力产生代理的不同类别的独家描述性分类，同时代表相关研究作品。还进行了概述以描述在体外或体内评估这些剂型的浮动行为的相关技术。最后，采用代表FDA批准的浮动药物产品的集合，并强调每种产品中使用的浮力发电剂类型。本文对发布后审查开放。注册读者（参见“对于读者”）可以通过单击“问题的内容”页面上的“摘要”来评论。

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