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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >The Effect of Diuretics on Patients with Heart Failure: A Network Meta-Analysis: Diuretics Effect on Heart Failure Patients
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The Effect of Diuretics on Patients with Heart Failure: A Network Meta-Analysis: Diuretics Effect on Heart Failure Patients

机译：利尿剂对心力衰竭患者的影响：网络荟萃分析：对心力衰竭患者的利尿作用

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Purpose: We aimed to comprehensively evaluate the curative effect of torasemide, tolvaptan, furosemide and azosemide on patients with heart failure. Methods: Relevant studies were retrieved by searching the electronic databases until May 2018. Quality assessment and data extraction of selected studies were evaluated by two reviewers. Heterogeneity across studies was assessed utilizing the I2 statistic and Q-test, and appropriate effect model was selected to calculate the pooled effect size. Network meta-analysis was conducted and the convergence degree of model was evaluated. Results: A total of 12 studies were enrolled in this study. Significant heterogeneity was not identified across the studies. Significantly greater differences were found in left ventricular ejection fraction (LVEF) for furosemide VS. azosemide, in brain natriuretic peptide (BNP) for furosemide VS. azosemide and furosemide VS. torasemide, and in adverse effects for furosemide VS. torasemide through Meta-analysis of direct comparison. In addition, network meta-analysis results suggested there were no significant differences in adverse effects, mortality, BNP and LVEF among these groups. However, the relatively low mortality and small improvement of BNP and LVEF were found in HF patients treated with torasemide. Conclusion: Torasemide might be an optimal treatment for HF patients considering its comprehensive curative effect.
机译：目的：我们旨在全面评估托塞膜，托尔瓦替丹，呋塞米和唑胺对心力衰竭患者的疗效。方法：通过搜索电子数据库来检索相关研究，直到2018年5月。由两位审稿人评估所选研究的质量评估和数据提取。利用I2统计和Q-Test评估研究的异质性，并选择适当的效果模型来计算汇总效果大小。进行网络元分析，评估模型的收敛程度。结果：本研究共有12项研究。在这些研究中未发现显着的异质性。在呋塞米的左心室喷射部分（LVEF）中发现显着更大的差异与呋塞米脑钠肽（BNP）中的含唑胺酰胺与唑胺和呋塞米与托罗塞米，对呋塞米的不利影响与通过直接比较的荟萃分析来扭结。此外，网络元分析结果表明这些群体中不良反应，死亡率，BNP和LVEF没有显着差异。然而，在用托塞膜治疗的HF患者中发现了BNP和LVEF的相对较低的死亡率和小于改善。结论：考虑其综合疗效的HF患者，Torasemide可能是最佳的治疗方法。

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