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首页> 外文期刊>Journal of Pharmacy and Pharmaceutical Sciences >Drugs Loaded into Electrospun Polymeric Nanofibers for Delivery
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Drugs Loaded into Electrospun Polymeric Nanofibers for Delivery

机译：装载到Electromat聚合物纳米纤维中的药物进行递送

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The electrospinning technique is a useful and versatile approach for conversion of polymeric solutions into continuous fibers, ranging from a few micrometers (10–100 μm) to the scale of nanometers (10–100 nm) in diameters. This technique can be used in a vast number of polymers, in some cases after modifying them to the required properties. The high surface-to-volume ratio of the fibers can improve some processes like cell binding and proliferation, drug loading, and mass transfer processes. One of the most important and studied areas of electrospinning is in the drug delivery field, for the controlled release of active substances ranging from antibiotics and anticancer agents, to macromolecules such as proteins and DNA. The advantage of this method is that a wide variety of low solubility drugs can be loaded into the fibers to improve their bioavailability or to attain controlled release. This review presents an overview of the reported drugs loaded into electrospun polymeric nanofibers to be used as drug delivery systems. These drugs are classified by their applications in pharmacy.
机译：静电纺丝技术是一种有用而通用的通用方法，用于将聚合物溶液转化为连续纤维，从少量微米（10-100μm）到直径的纳米（10-100nm）的等级范围。在将它们修改到所需性质之后，在一些情况下，该技术可用于大量聚合物。纤维的高度体积比可以改善细胞结合和增殖，药物载荷和传质过程等一些方法。静电纺丝最重要和研究领域之一是药物递送领域，用于控制源自抗生素和抗癌剂的活性物质，诸如蛋白质和DNA的大分子。该方法的优点是可以将各种低溶解性药物装载到纤维中以改善其生物利用度或获得控制释放。本综述概述了将报告的药物概述加载到Electropul聚合物纳米纤维中以用作药物递送系统。这些药物通过其在药房的应用来归类。

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