• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Research in Dental Sciences >Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst
【24h】

Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst

机译：异肠囊肿表现表皮生长因子受体的表达：心肌囊肿和牙突角囊腺的比较研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract: Background and Aim: Compare with Dentigerous cyst, Odontogenic Keratocyst is one of exclusive developmental cyst with unique clinical and histopathologic features.Considering the determining role of epidermal growth factor receptor (EGFR) in cell proliferation and survival, and the controversial results of previous studies regarding the expression of this marker by the odontogenic cysts, this study aimed to compare the expression of EGFR marker by Dentigerous cyst (DC) and odontogenic Keratocyst (OKC) as two lesions with more common neoplastic transformation.Material and methods: In this experimental study, 49 specimens (23 DCs and 26 OKCs) were evaluated.Immunohistochemical staining was performed using EGFR antibody.Evaluation of EGFR expression was made regarding to Tie-JUN Li et al.So, The location of EGFR expression in the epithelial cells ( Basal layers, Suprabasal basal , All layeres) were assessed through histopathologic sections..Data were analyzed using the Mann-Whitney test, t-test and chi-square test.Results: In The present Study, of 49 evaluated cases, the mean percentage of EGFR expression was 58.2017.97% in the 23 DC and 78.0519.27% in the 26 OKC specimens.The EGFR expression of OKC was significantly higher than DC (P=0.001).However, the Mann-Whitney test showed no significant difference regarding EGFR score (P=0.144).The chi-square test revealed no significant difference in expression of EGFR in the basal layer, basal and suprabasal layers and all layers (P=0.524).Conclusions: The expression of EGFR marker in OKC was significantly higher than in DC, which may justify the progressive growth potential of OKC.
机译：摘要：背景和目的：与心脏囊肿的比较，odontogenic角膜囊肿是独特的临床和组织病理学特征的独家发育囊肿之一。表皮生长因子受体（EGFR）在细胞增殖和生存中的确定作用，以及之前的争议结果本研究表达该标志物的表达，该研究旨在将EGFR标记物的表达与牙本质囊肿（DC）和odontogeCheratoCyst（OKC）的表达进行比较，作为具有更常见的肿瘤转化的两个病变。材料和方法：在这种实验中评估49种样品（23dCs和26个OKC）。使用EGFR抗体进行免疫组化染色。EGFR表达的评估是关于TIE-JUN LI等，在上皮细胞中EGFR表达的位置（基础通过组织病理学部分评估层，Suprabasal基础，所有层）。使用曼恩 - 惠特分析Data Ney Test，T-Test和Chi-Square Test.results：在本研究中，在49例评估病例中，23dC在23dC和78.0519.27％中的平均百分比为26个OKC样本。 OKC的EGFR表达明显高于DC（P = 0.001）。然而，人体惠特尼试验没有关于EGFR得分的显着差异（P = 0.144）。奇方检验显示EGFR表达没有显着差异基底层，基础和超级层和所有层（P = 0.524）。结论：OKC中EGFR标志物的表达显着高于DC中，这可以证明OKC的逐步生长潜力合理。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号