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首页> 外文期刊>Journal of the International Society of Sports Nutrition >Acute effects of Nitrosigine? and citrulline malate on vasodilation in young adults
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Acute effects of Nitrosigine? and citrulline malate on vasodilation in young adults

机译：亚硝素苷的急性作用？和瓜氨酸在年轻成年人血管血清

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BACKGROUND:Athletes are increasingly exploring ways to enhance their physical performance. Increasing blood flow to the working tissues through endothelium-dependent vasodilation is one factor athletes use to realize these results. Sports supplements such as pre-workouts tout this benefit; however, many have not been tested under laboratory conditions to examine the effects of commonly used supplements on vasodilation. Two popular supplements are Nitrosigine? and citrulline malate (CM). Thus, the purpose of this experiment was to determine the effective of Nitrosigine and CM on vasodilation using ultrasound and flow mediated dilation (FMD).METHODS:Healthy, normotensive, and physically active male (n?=?16) and female (n?=?8) young adults participated in the present investigation. We utilized a randomized, double-blind, within-subjects design where participants reported for three trials, each preceded by a 7-day washout period. Baseline FMD measurement was obtained for each visit, followed by consumption of one clinical dose CM (8?g), Nitrosigine (1.5?g), or dextrose placebo (8?g). Following a 60-min digestion period, FMD was repeated. Supplementation order was randomized controlling for potential order effects.RESULTS:Repeated measures ANOVA yielded a significant supplement (3) x time (2) effect (p??.001), such that Nitrosigine and CM yielded a greater improvement in FMD response than placebo. After supplementation, Nitrosigine and CM increased FMD by 31 and 34%, respectively, compared to a decrease of 2% during the placebo trial. After allometric scaling of the FMD values, supplement x time effect remained significant (p?=?.001) and changes were similar to non-scaled results. Nitrosigine (23%) and CM (25%) generated significantly greater allometric scaled FMD values when compared to the placebo trail (0.60%).DISCUSSION:Both Nitrisigine and CM increased endothelial-dependent vasodilation as measured by a change in FMD. Increased vasodilation leads to an increase in skeletal muscle blood flow resulting in potential improvements in exercise performance.
机译：背景：运动员越来越多地探索提高其体能的方法。通过内皮依赖性血管血管增加对工作组织的血流是一个因素运动员，用于实现这些结果。运动补充剂如锻炼前吹嘘这一福利;然而，许多人尚未在实验室条件下进行测试，以检查常用补充剂对血管舒张的影响。两种流行的补充剂是亚硝基胺？和瓜氨酸苹果酸（cm）。因此，该实验的目的是使用超声和流动介导的扩张（FMD）测定亚硝基和Cm对血管舒张的有效性。方法：健康，正常，身体活性的雄性（N？=？16）和女性（n？ =？8）年轻人参加了目前的调查。我们利用随机的双盲，在受试者内设计，参与者报告的三项试验，每个试验期间，每个试验在7天的洗涤期之前。获得基线FMD测量每次访问，然后消耗一种临床剂量cm（8μl），亚硝胺（1.5 ~g）或右旋糖安慰剂（8μl）。在60分钟的消化期之后，重复FM​​D。补充顺序是随机控制潜在的命令效应。结果：反复测量ANOVA产生显着的补充剂（3）X时间（2）效应（P？<= 001），使得亚硝基和CM产生更大的FMD响应改善安慰剂。在补充后，亚硝酸甲胺和CM分别在安慰剂试验期间减少2％的减少而增加了31％和34％。在FMD值的同传缩放之后，补充X时间效应仍然很大（P？=Δ.001）和变化类似于非缩放结果。与安慰剂路径相比（0.60％）相比，亚硝基胺（23％）和cm（25％）产生显着更大的缩放FMD值。讨论：通过FMD的变化测量，NITRISIGIN和CM增加了内皮依赖性血管舒张。增加的血管沉积导致骨骼肌血流的增加导致运动性能的潜在改善。

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