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首页> 外文期刊>Journal of the Endocrine Society. >SUN-LB104 Metabolic Inflexibility: Is It a Feature of Obesity or a Characteristic of Metabolically Unhealthy Youth?
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SUN-LB104 Metabolic Inflexibility: Is It a Feature of Obesity or a Characteristic of Metabolically Unhealthy Youth?

机译：Sun-Lb10​​4代谢inf灵活性：是肥胖的特征还是代谢上不健康青年的特征？

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Obese individuals have metabolic inflexibility evidenced by diminished fasting fat oxidation and blunted increase in respiratory quotient (RQ) from fasting to insulin-stimulated state. Metabolically unhealthy obese (MUHO) adolescents, unlike their metabolically healthy obese (MHO) peers, have unfavorable metabolic characteristics despite having comparable adiposity. We investigated if metabolic inflexibility is a characteristic of obesity per se or is unique to MUHO compared with MHO youth. Obese youth (n=188; age 14.1 ± 0.1 yrs [SE]; BMI 33.6 ± 0.4 kg/m2) were divided into 137 MUHO (age 14.1 ± 0.2 yrs; BMI 35.4 ± 0.5 kg/m2) and 51 MHO (age 13.9 ± 0.3 yrs; BMI 29.0 ± 0.7 kg/m2) based on cut points for in vivo insulin sensitivity (IS) [MHO within 1.5 SD and MUHO 1.5 SDs of 72 normal-weight (NW) adolescents’ IS values]. RQ (by indirect calorimetry) at fasting and during a hyperinsulinemic (80mu/m2/min)-euglycemic clamp was measured, and ?RQ calculated. Body composition (by DEXA), visceral adipose tissue (VAT) (by CT and MRI), hepatic IS (HIS) (calculated from fasting hepatic glucose production by [6,6-2H2]glucose and fasting insulin), adipose IS (ATIS) (calculated from whole body lipolysis by [2H5]glycerol and fasting insulin), and peripheral IS were assessed. MUHO vs. MHO youth had blunted ?RQ (0.088 ± 0.004 vs. 0.107 ± 0.007, p=0.035), but MHO was not different from NW (0.098 ± 0.004, p=0.893). Further, MUHO vs. MHO youth had lower HIS (15.3 ± 0.7 vs. 24.3 ± 1.6 (mg/kg/min·uU/mL)-1, p0.0001) and lower ATIS (9.8 ± 0.5 vs. 22.3 ± 3.1 (umol/kg/min·uU/mL)-1, p0.0001), but HIS and ATIS were not different between MHO and NW youth (24.3 ± 1.6 vs. 20.8 ± 1.2 (mg/kg/min·uU/mL)-1, and 22.3 ± 3.1 vs. 22.0 ± 1.4 (umol/kg/min·uU/mL)-1, p=ns for both). ?RQ correlated with HIS (r=0.535), ATIS (r=0.288) and VAT (r=-0.309) (p0.0001 for all), but not with BMI, BMI Z-scores or % body fat. The differences between MUHO and MHO youth in ?RQ, HIS and ATIS remained significant after adjusting for % body fat, race, pubertal status and VAT. The present study reveals that metabolic inflexibility is not a feature of obesity, rather it is a characteristic of MUHO youth who have significantly lower ?RQ compared with MHO youth, with no difference between MHO and NW youth. Moreover, MUHO compared with MHO youth have worse metabolic profile, represented in lower HIS and ATIS.
机译：肥胖个体具有代谢的抑制性，通过减少空腹脂肪氧化和呼吸型商（RQ）的增加，从禁食到胰岛素刺激状态。尽管具有相当的肥胖，但与其代谢健康的肥胖（MHO）同伴不同，代谢不健康的肥胖（MUHO）青少年具有不利的代谢特征。我们调查了代谢抑制性是肥胖症本身的特征，或者与MHO青年相比，Muho是独一无二的。肥胖的青年（n = 188;年龄14.1±0.1yrs [se]; bmi 33.6±0.4 kg / m2）分为137 muho（年龄14.1±0.2yrs; bmi 35.4±0.5 kg / m2）和51 mho（13.9岁）基于体内胰岛素敏感性的切割点（IS）[MHO，在1.5 SD和72个正常重量（NW）青少年的MHO内，基于±0.3 YRS; BMI 29.0±0.7 kg / m2）。 RQ（间接量热法）在禁食和高胰岛素血症（80Mu / M2 / min）期间进行测量，并计算rQ。身体成分（通过DEXA），内脏脂肪组织（VAT）（通过CT和MRI），肝脏（他）（通过[6,6-2H2]葡萄糖和空腹胰岛素计算的肝葡萄糖产生），脂肪是（ATIS ）（通过[2H5]通过[2H5]脂溶液从全身脂解）进行评估和外周。 Muho与MHO青年钝了？RQ（0.088±0.004，0.107±0.007，P = 0.035），但MHO与NW不同（0.098±0.004，p = 0.893）。此外，MUHO与MHO青年（15.3±0.7 vs.24.3±1.6（mg / kg / min·UU / ml）-1，p <0.0001）和下atis（9.8±0.5与22.3±3.1（ UMOL / kg / min·UU / ml）-1，p <0.0001），但他和尼斯在MHO和NW青年之间没有差异（24.3±1.6对20.8±1.2（Mg / kg / min·UU / ml）之间-1，和22.3±3.1与22.0±1.4（Umol / kg / min·Uu / ml）-1，p = ns）。 ？RQ与他（r = 0.535），ATIS（r = 0.288）和vat（r = -0.309）（p <0.0001）相关，但不适用于BMI，BMI Z分数或％体脂。 Muho和MHO青年之间的差异在？RQ，他和ATIS在调整％体脂，种族，青春期地位和增值税后仍然显着。本研究表明，代谢屈心不合格不是肥胖症的特征，而是穆哈青年的特征，与MHO青年相比，MOHO青年的特点，MHO和NW青年之间没有区别。此外，与MHO青年相比，Muho具有更糟糕的代谢外形，其较低的他和ATIS表示。

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