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首页> 外文期刊>Journal of the Endocrine Society. >MON-584 Albuminuria and Obesity - Which Are the Associated Factors?
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MON-584 Albuminuria and Obesity - Which Are the Associated Factors?

机译：mon-584白蛋白尿和肥胖 - 这是相关因素吗？

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Introduction The association between obesity and renal dysfunction has been widely studied. Albuminuria is a cardiovascular risk factor and the most prevalent marker of kidney injury in people with obesity. Despite the higher prevalence of hypertension and diabetes in those patients, other contributing factors are still unknown. We aimed to explore the factors related to albuminuria in obesity, analyzing its variation after bariatric surgery. Methods We evaluated 2518 patients undergoing bariatric surgery, of those, 1243 with preoperative albuminuria measurement were included in this study. Albuminuria was determined by the albumin-creatinine ratio (RAC) in an occasional urine sample (mg/g) or by the 24-hour urine albumin excretion rate (TEA) (mg/24h). Means and medians were compared using Student’s T-test or Mann-Whitney tests, respectively. Spearman correlation was used. Results Age (ρ = 0.073; p = 0.010), body mass index (BMI) (ρ = 0.139; p 0.001), waist circumference (WC) (ρ = 0.220; p 0.001), glycated hemoglobin (HbA1C) (ρ = 0.221; p 0.001), systolic blood pressure (SBP) (ρ = 0.203; p 0.001), diastolic blood pressure (DBP) (ρ = 0.134; p 0.001), uricemia (ρ = 0.141; p 0.001) and C-reactive protein (CRP) levels (ρ = 0.090; p = 0.017) were positively correlated with albuminuria.Patients with albuminuria (TEA / RAC≥30) had higher BMI (45.0 ± 6.0 vs.43.2 ± 5.6kg / m2; p 0.001), WC (129.3 ± 13.1 vs. 122.0 ± 12.9cm; p 0.001), SBP (142.7 ± 18.0 vs.134.1 ± 16.5mmHg; p 0.001), DBP (88.0 ± 12.6 vs.83, 2 ± 10.3mmHg; p 0.001), uricemia (6.1 ± 1.5 vs.5.4 ± 1.4mg / dL; p 0.001) and CRP (11.3 (16.4) vs.8, 3 (9.6) mg / L; p 0.001).Excluding patients with diabetes and hypertension, BMI and WC remained statistically positively correlated with urinary albumin excretion. After surgery, the decrease of albuminuria was correlated with the reduction of HbA1C (ρ = 0.144; p 0.001) and CRP (ρ = 0.113; p = 0.037). Conclusion Anthropometric, inflammatory and metabolic factors, namely WC, CRP and uricemia, may be involved in the etiopathogenesis of albuminuria in obese patients. Bariatric surgery is the most effective method to reverse obesity and it has been shown to be a promising therapy on the treatment of associated renal dysfunction.
机译：引言肥胖与肾功能障碍之间的关联已被广泛研究。白蛋白尿是一种心血管危险因素和肥胖人民肾损伤最普遍的标记。尽管这些患者的高血压和糖尿病患病率较高，但其他贡献因素仍然未知。我们的旨在探讨肥胖症中与白蛋白尿有关的因素，分析了肥胖症手术后的变异。方法我们评估了2518例经过培育术术患者，其中1243例，术前与术前白蛋白尿测量均包括在本研究中。白蛋白尿素由白蛋白 - 肌酐比（RAC）在偶尔尿液样品（Mg / g）中或通过24小时尿蛋白酶排泄率（Mg / 24h）。使用学生的T-Test或Mann-Whitney测试进行比较手段和中位数。使用Spearman相关性。结果年龄（ρ= 0.073; P = 0.010），体重指数（BMI）（ρ= 0.139; P <0.001），腰围（WC）（ρ= 0.220; p <0.001），糖化血红蛋白（HBA1c）（ρ= 0.220; p <0.001）（ρ = 0.221; P <0.001），收缩压（SBP）（ρ= 0.203; P <0.001），舒张压（DBP）（ρ= 0.134; P <0.001），尿道（ρ= 0.141; P <0.001）和C-反应性蛋白（CRP）水平（ρ= 0.090; p = 0.017）与白粉尿蛋白尿阳性相关。用白蛋白尿（TEA /RAC≥30）的BMI具有较高的BMI（45.0±6.0 Vs.43.2±5.6kg / m2; P <0.001），WC（129.3±13.1与122.0±12.9cm; P <0.001），SBP（142.7±18.0 Vs.134.1±16.5mmHg; P <0.001），DBP（88.0±12.6 Vs.83,2± 10.3mmhg; p <0.001），尿牛（6.1±1.5 Vs.5.4±1.4mg / dl; p <0.001）和CRP（11.3（16.4）vs.8,3（9.6）mg / L; p <0.001）。不包括糖尿病和高血压的患者，BMI和WC与尿白蛋白排泄保持统计呈正相关。手术后，与HBA1C的还原（ρ= 0.144; p <0.001）和CRP（ρ= 0.113; p = 0.037）相关的蛋白核尿的降低。结论人类计量，炎症和代谢因素，即WC，CRP和尿道血症，可参与肥胖患者白蛋白尿的病因发生。肥胖的手术是最有效的逆转肥胖方法，并且已被证明是对治疗相关肾功能障碍的有希望的治疗。

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