...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of the Endocrine Society. >SAT-166 Advantage and Trustworthy of Cortisol and Dexamethasone Evaluation in Different Biological Matrices in Patients with Adrenal Masses
【24h】

SAT-166 Advantage and Trustworthy of Cortisol and Dexamethasone Evaluation in Different Biological Matrices in Patients with Adrenal Masses

机译：SAT-166肾上腺肿块患者的不同生物学基质中的皮质醇和地塞塞索斯的优势和依赖性。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Biochemical function of adrenal masses is currently based on 1mg post-overnight dexamethasone suppression test (pDST). Several approaches are recently developed, in order to reduce false positive/negative samples, only in retrospective series. They are based on the correlation of some different parameters, i.e. late-night salivary cortisol (LNSC) vs serum and salivary cortisol pDST; LNSC vs serum and salivary cortisol and serum dexamethasone pDST; LNSC and cortisone vs serum cortisol and salivary cortisol and cortisone pDST. Although these findings offer a better diagnostic performance, several conditions are still disappointed. No information is traceable about the harvest time of diurnal salivary and serum samples and no study include neither the levels of salivary nor urinary dexamethasone pDST. Aim of our study is to combine all these strategies in order to avoid the underestimated biases and obtain more precise information about the true “cortisol condition” of the patients. To reach this purpose we assess both cortisol and dexamethasone concentrations in several samples: saliva at 11PM before the drug administration, diurnal saliva and serum at 8AM and also the urine collection from 11PM to 8AM. Analytes levels are measured using a validated liquid chromatography-tandem mass spectrometry method. In this study we included 20 subjects without morphological adrenal alteration (MRI assessment), dyslipidemia, hypertension and impaired glucose tolerance (healthy controls) and 20 patients with adrenal incidentaloma showing different cortisol levels ranging from normal to ACTH-independent hypercortisolism. In both series, LNSC were similar to salivary cortisol pDST, even if they were greater in the patients with adrenal incidentalomas and subclinical cortisol secretion. Serum dexamethasone levels were in reference ranges, while salivary and urinary dexamethasone found in these matrices require additional sample numbers in order to establish appropriate cut-offs. Our preliminary results suggest that the combination of these findings could represent an improvement to assess the individual cortisol status.
机译：肾上腺素的生化功能目前基于1mg后过夜地塞米松抑制试验（PDST）。最近开发了几种方法，以减少假阳性/阴性样本，只在回顾性系列中。它们基于一些不同参数的相关性，即深夜唾液皮质醇（LNSC）与血清和唾液皮质醇PDST; LNSC与血清和唾液皮质醇和血清Dexamethasone PDST; LNSC和可鞘豆与血清皮质醇和唾液皮质醇和可溶态PSTST。虽然这些发现提供了更好的诊断表现，但有几个条件仍然失望。没有信息可追溯到日唾液和血清样品的收获时间，并且没有研究既不包括唾液也不包括泌尿程度，也不是泌尿式地塞米松PDST。我们的研究目的是结合所有这些策略，以避免低估的偏差，并获得有关患者真实“皮质状况”的更精确的信息。为达到此目的，我们将皮质醇和地塞米松浓度评估在几个样品中：唾液11点在药物管理前11点，早上8点的唾液和血清，尿液收集从上午11点至8点。使用验证的液相色谱 - 串联质谱法测量分析物水平。在这项研究中，我们包括20个受试者，没有形态肾上腺改变（MRI评估），血脂血症，高血压和葡萄糖耐量（健康对照）和20例肾上腺梗死患者，显示出不同的皮质醇水平，从正常到独立于动力的高旋转性。在两种系列中，即使患者肾上腺切除症和亚临床皮质醇分泌患者，LNSC也类似于唾液皮质醇PDST。血清地塞米松水平是参考范围，而在这些基质中发现的唾液和尿状物是需要额外的样品号，以便建立适当的截止值。我们的初步结果表明，这些发现的组合可能代表评估单个皮质醇地位的改进。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号