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首页> 外文期刊>Journal of Tropical Medicine >Declining Trends in Childhood TB Notifications and Profile of Notified Patients in the City of Harare, Zimbabwe, from 2009 to 2018
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Declining Trends in Childhood TB Notifications and Profile of Notified Patients in the City of Harare, Zimbabwe, from 2009 to 2018

机译：从2009年到2018年，津巴布韦（Harare）市童年结核病通知和通知患者概况下降趋势

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Globally, childhood tuberculosis (TB among those aged 15 years) is a neglected component of national TB programmes in high TB burden countries. Zimbabwe, a country in southern Africa, is a high burden country for TB, TB-HIV, and drug-resistant TB. In this study, we assessed trends in annual childhood TB notifications in Harare (the capital of Zimbabwe) from 2009 to 2018 and the demographic, clinical profiles, and treatment outcomes of childhood TB patients notified from 2015–2017 by reviewing the national TB programme records and reports. Overall, there was a decline in the total number of TB patients (all ages) from 5,943 in 2009 to 2,831 in 2018. However, the number of childhood TB patients had declined exponentially 6-fold from 583 patients (117 per 100,000 children) in 2009 to 107 patients (18 per 100,000 children) in 2018. Of the 615 childhood TB patients notified between 2015 and 2017, 556 (89%) patient records were available. There were 53% males, 61% were aged 5 years, 92% were new TB patients, 85% had pulmonary TB, and 89% were treated for-drug sensitive TB, 3% for drug-resistant TB, and 40% were HIV positive (of whom 59% were on ART). Although 58% had successful treatment outcomes, the treatment outcomes of 40% were unknown (not recorded or not evaluated), indicating severe gaps in TB care. The disproportionate decline in childhood TB notifications could be due to the reduction in the TB burden among HIV positive individuals from the scale up of antiretroviral therapy and isoniazid preventive therapy. However, the country is experiencing economic challenges which could also contribute to the disproportionate decline in childhood TB notification and gaps in quality of care. There is an urgent need to understand the reasons for the declining trends and the gaps in care.
机译：在全球范围内，儿童结核病（TB中的患者<15岁）是在高结核病国家的国家结核病项目的被忽视的成分。津巴布韦是一个南部非洲的国家，是Tb，Tb-Hiv和耐药TB的高负担国家。在本研究中，我们从2009年到2018年的哈拉雷（津巴布韦的首都）评估了每年儿童结核病通知的趋势，并通过审查国家结核计划记录，从2015-2017通知的儿童结核病患者的人口统计学，临床曲线和治疗结果和报告。总体而言，从2009年的5,943岁的TB患者（所有年龄段）的总数减少到2018年的2,831名。然而，儿童TB患者的数量从583名患者（每10万名儿童117名儿童117名儿童）下降6倍2018年2009年至107名患者（每10万人18例儿童）。在2015年至2017年间通知的615名儿童TB患者中，556名（89％）患者记录可获得。男性53％的男性，61％均为<5岁，92％是新的TB患者，85％具有肺结核，89％的药物敏感TB处理，耐药TB的3％，40％艾滋病毒阳性（其中59％在艺术品上）。虽然58％的治疗结果成功，但40％的治疗结果未知（未记录或未评估），表明TB护理中的严重间隙。儿童结核病通知的不成比例下降可能是由于抗逆转录病毒治疗和异烟预防治疗的艾滋病毒阳性患者的结核病负担的降低。然而，该国正在经历经济挑战，这也可能导致童年结核病通知和在护理质量差距的不成比例下降。迫切需要了解趋势下降的原因和护理的差距。

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