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首页> 外文期刊>Journal of Young Pharmacists >Evaluation of Hepatotoxicity of Anti-Tuberculosis Regimens: A Prospective Study in Tribal Population of Central India
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Evaluation of Hepatotoxicity of Anti-Tuberculosis Regimens: A Prospective Study in Tribal Population of Central India

机译：抗结核方案肝毒性评价：印度中部部落人群的前瞻性研究

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Background: The magnitude of tuberculosis (TB) and associated risk factors for development of toxicity to anti-TB drugs in vulnerable tribal groups are useful indicators for understanding extent of TB transmission, effectiveness of TB therapy. Such studies help to gather information, helps in planning control and preventive strategies for TB in this special population. The study was carried out to evaluate incidence of hepatotoxicity, association between risk factors, anti-TB regimen and hepatotoxicity in selected vulnerable population. Materials and Methods: Prospective study in tribes (Gond, Halba, Kawar) of a district in central India diagnosed with pulmonary/ extrapulmonary/Multi drug resistant TB. These patients were on anti- TB regimen, monitored clinically and biochemically for hepatotoxicity at the end of 1, 3 and 6 months of anti-tubercular therapy. A specific criterion was set for diagnosing hepatotoxicity. Results: Incidence of hepatotoxicity was 9.23%. Raised serum transaminase, bilirubin level and symptoms of hepatotoxicity like nausea, anorexia, vomiting, malaise, jaundice, were observed. The onset of hepatotoxicity ranged from 25-180 days (median 65 days). Of various risk factors analyzed, high alcohol intake was associated with hepatotoxicity (odds ratio = 9.3, 95% confidence interval 1.8–47, p=0.003). Age, gender, extent of tuberculosis disease, malnutrition was not significantly associated with anti-tuberculosis treatment hepatotoxicity. Relative risk of developing hepatotoxicity in alcoholic addicted males was 14.117. Conclusion: Withdrawal of alcohol habit in selected tribes on anti- Tuberculosis regimen will cause a drop in developing hepatotoxicity by 93%. Mass education regarding same would curtail hepatotoxicity making therapy safe.
机译：背景：脆弱部落群体对抗结核药物毒性毒性发展的结核病（TB）和相关危险因素是了解结核病传播程度，结核病治疗的有效性的有用指标。这些研究有助于收集信息，有助于在这一特殊人口中规划控制和预防性战略。该研究进行了评估肝毒性的发病率，风险因素，抗结核病方案和肝毒性在所选择的脆弱群体之间的发病率。材料与方法：中印地区地区部落（GOND，HALBA，KAWAR）的前瞻性研究诊断出患有肺/外尿/多药物抗性TB。这些患者在抗结核病方案上，在抗结核治疗的1,3和6个月结束时临床和生物化学针对肝毒性监测。为诊断肝毒性而设定了具体标准。结果：肝毒性发生率为9.23％。观察到培养的血清转氨酶，胆红素水平和肝毒性等肝毒性，如恶心，厌食症，呕吐，萎靡不振，黄疸，黄疸。肝毒性的发病范围从25-180天（中位数65天）。分析各种风险因素，高级酒精摄入与肝毒性有关（差距= 9.3,95％置信区间1.8-47，P = 0.003）。年龄，性别，结核病的程度，营养不良与肝毒性没有显着相关。在酒精上瘾的男性中发育肝毒性的相对风险为14.117。结论：在选定的抗结核方案中取出酒精习性将导致肝毒性的下降93％。群众教育也将削减肝毒性使治疗安全。

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