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首页> 外文期刊>Journal of Young Pharmacists >Supplementation of Carica papaya Leaves (Carica papaya L.) in Nori preparation Reduced Blood Pressure and Arterial Stiffness on Hypertensive Animal Model
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Supplementation of Carica papaya Leaves (Carica papaya L.) in Nori preparation Reduced Blood Pressure and Arterial Stiffness on Hypertensive Animal Model

机译：Carica Papaya叶（CaricaPapaya L.）在诺里制备降低血压和高血压动物模型中的动脉僵硬

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Objectives: Hypertension is defined as an increase in systolic and/or diastolic blood pressure of more than 140/90 mmHg. Epidemiological studies showed that there is a relationship between hypertension and the incidence of arterial stiffness, especially in the elderly. Blood pressure management aims to prevent damage to various target organs such as the heart, brain, kidneys, eyes and peripheral arteries. Papaya leaves ( Carica papaya L.) have been known empirically to treat hypertension. This study aimed to determine the effect of papaya leaves processed into Nori preparation on blood pressure and arterial stiffness. Methods: This study was carried out on animal models of male Wistar rats induced hypertension. A total of 30 male-Wistar rats were randomly divided into 6 groups consisting of control negative group and control positive group (received drug carriers), the group received captopril 2.5 mg/kg and groups received Nori of papaya leaves 5, 10 and 20% in their diet. All groups except the control negative group received 66% fructose in their food for 21 days. Parameters measured were systolic and diastolic blood pressure, pulse wave velocity (PWV) on days 0, 7, 14 and 21 after treatment. Results: The group received Nori 10% showed normalize both systolic and diastolic blood pressure and a decreased in arterial stiffness compared to the group received captopril ( p 0.05). Conclusion: It can be concluded that papaya leaves in Nori preparation is effective as an antihypertensive and reduced arterial stiffness.
机译：目的：高血压定义为收缩性和/或舒张血压的增加超过140/90mmHg。流行病学研究表明，高血压与动脉僵硬的发生率之间存在关系，尤其是老年人。血压管理旨在防止损害各种靶器官，如心脏，脑，肾脏，眼睛和外周枢动脉。番木瓜叶（CaricaPapaya L.）凭经验地享有治疗高血压。本研究旨在确定番木瓜叶片加工成诺里制剂对血压和动脉刚度的影响。方法：本研究进行了雄性Wistar大鼠诱导高血压的动物模型。将总共​​30只雄性Wistar大鼠随机分为6组，组成6组，组成的对照负组和对照阳性组（接受药物载体），该组接受Captopril 2.5mg / kg和群体葡萄鱼叶5,10％和20％在他们的饮食中。除控股负数外，所有群体在其食物中收到66％的果糖21天。测量的参数是收缩和舒张压，脉搏波速度（PWV）在治疗后的第0,7,14和21天。结果：该组接受NORI 10％显示，与所接受的CAPTOPLIL（P> 0.05）相比，动脉僵硬度的标准化标准化。结论：可以得出结论，诺伊制剂中的木瓜叶是有效的抗高血压和降低的动脉僵硬。

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