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首页> 外文期刊>Journal of Transfusion >An Efficient Apparatus for Rapid Deoxygenation of Erythrocyte Concentrates for Alternative Banking Strategies
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An Efficient Apparatus for Rapid Deoxygenation of Erythrocyte Concentrates for Alternative Banking Strategies

机译：用于替代银行策略的红细胞浓缩物快速脱氧的一种有效液

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摘要

Erythrocyte concentrates (ECs) stored for transfusion purposes still represent a lifesaving solution in a wide series of clinically occurring circumstances, especially for traumatized and perioperative patients. However, concerns still arise and persist as to whether current criteria for collection and storage of ECs might actually represent the best case scenario or there might rather be still room for improvement. In particular, the prolonged storage of EC has been associated with the accumulation of a wide series of storage lesions, either reversible (metabolism) or irreversible (protein and morphology). Independent laboratories have contributed to propose alternative strategies, among which is the introduction of oxygen removal treatments to ECs. Convincing biochemical and preliminary clinical evidences have been produced about the benefits derived from the introduction of this practice. We, hereby, propose a rapid, efficient, and time-effective strategy for blood deoxygenation which might fit in current EC production chain. The proposed strategy resulted in the complete deoxygenation of red blood cell hemoglobin ( mmHg). A preliminary small-scale study about the application of the present method resulted in reduced hemolysis, decreased vesiculation, and limited alterations to the red blood cell morphology, as gleaned from flow cytometry and scanning electron microscopic analyses. Further in-depth and larger-scale investigations are encouraged.
机译：用于输血的红细胞浓缩物（ECS）仍然代表着各系列临床发生的环境中的救生溶液，特别是对于受伤和围手术期患者。然而，仍然存在令人担忧，并持续到E​​CS的收集和储存的当前标准是否可能实际上代表最佳案例场景，或者可能仍然存在改善仍然是仍然的余地。特别地，EC的延长储存已经与宽系列储存病变的积累有关，可逆（代谢）或不可逆转（蛋白质和形态）。独立实验室有助于提出替代策略，其中包括引入ECS的氧去除治疗方法。令人信服的生化和初步临床证据已经产生了引入这种做法的益处。我们在此提出了适合当前EC生产链的血液脱氧的快速，高效，有效的策略。所提出的策略导致红细胞血红蛋白（mmHg）的完全脱氧。关于本方法的应用的初步小规模研究导致溶血降低，减少的混血率和对红细胞形态的改变有限，从流式细胞术和扫描电子显微镜分析中收集。鼓励进一步深入和更大的调查。

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