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首页> 外文期刊>Journal of Translational Medicine >Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose–response meta-analysis of 33 randomized controlled trials
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Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose–response meta-analysis of 33 randomized controlled trials

机译：菊粉型Fructans补充改善了前奶脂菌和2型糖尿病群的血糖控制：33种随机对照试验的等级评估系统审查和剂量 - 反应荟萃分析的结果

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BACKGROUND:Currently, many clinical trials have shown that inulin-type fructans (ITF) supplementation is associated with glycemic control; nevertheless, the results are inconclusive. The aim of this meta-analysis of randomized controlled trials was to assess the effects of ITF supplementation on glycemic control.METHODS:PubMed, EMBASE and the Cochrane Library were searched for eligible articles up to March 6, 2019. A random-effects model was used to analyze the pooled results, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was applied to assess the quality of evidence. The dose-response model was used to recommend the daily dose and duration for ITF supplementation.RESULTS:Thirty-three trials involving 1346 participants were included. Overall, ITF supplementation could significantly reduce concentrations of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS) and homeostasis model assessment-insulin resistance (HOMA-IR). In the prediabetes and type 2 diabetes (T2DM) population, a more significant reduction in FBG [weighted mean difference (WMD): -?0.60?mmol/l; 95% CI -?0.71, -?0.48?mmol/l; high rate], HbA1c (WMD: -?0.58%; 95% CI -?0.83, -?0.32%; high rate), FINS (WMD: -?1.75?μU/ml; 95% CI -?2.87, -?0.63?μU/ml; low rate), and HOMA-IR (WMD: -?0.69; 95% CI -?1.10, -?0.28; low rate) were observed, and ITF supplementation with a daily dose of 10?g for a duration of 6?weeks and longer was recommended. Moreover, subgroup analyses suggested that the effects of glycemic control were significantly influenced by the sex of the subjects and the type and the method of intake of ITF.CONCLUSIONS:Our analyses confirmed that these four main glycemic indicators were significantly reduced by ITF supplementation, particularly in the prediabetes and T2DM population. Evidence supports that reasonable administration of ITF supplementation may have potential clinical value as an adjuvant therapy for prediabetes and T2DM management. Trial registration The trial was registered at PROSPERO as CRD42018115875 on November 23, 2018.
机译：背景：目前，许多临床试验表明，菊粉型Fructans（ITF）补充与血糖控制有关;然而，结果不确定。对随机对照试验的这种荟萃分析的目的是评估ITF补充对血糖控制的影响。在2019年3月6日的符合条件的文章中搜查了Pubmed，Embase和Cochrane图书馆。随机效果模型是用于分析汇总结果，并应用建议评估，发展和评估（等级）制度的评分评估证据质量。剂量 - 响应模型用于推荐每日剂量和ITF补充的持续时间。结果：包括三十三名涉及1346名参与者的试验。总体而言，ITF补充可以显着减少空腹血糖（FBG）的浓度，糖基化血红蛋白（HBA1C），空腹胰岛素（鳍）和稳态模型评估 - 胰岛素抵抗（HOMA-IR）。在预先抛火和2型糖尿病（T2DM）群体中，FBG的减少更大[加权平均差异（WMD）： - ？0.60？mmol / L; 95％CI - ？0.71， - ？0.48？mmol / L; HBA1C（WMD： - 〜0.58％; 95％CI - 〜0.83， - α0.32％），鳍（WMD： - α1.75≤1.75×μU/ ml; 95％CI - α2.87， - ？ 0.63Ωμu/ ml;低速率）和HOMA-IR（WMD： - ？0.69; 95％CI - ？1.10， - ？0.28;低速率），ITF补充每日剂量为10？G建议持续6个时间，更长时间。此外，亚组分析表明，血糖对照的影响受到受试者性别的影响以及ITF的摄入量和摄入方法。结论：我们的分析证实，ITF补充，这四种主要血糖指标明显减少了，特别是在Prediapetes和T2DM人口中。证据支持合理施用ITF补充可能具有潜在的临床价值，作为预先抛售和T2DM管理的辅助治疗。审判登记审判于2018年11月23日在Prospero注册为CRD42018115875。

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