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首页> 外文期刊>Journal of Thoracic Disease >Combining node location and node ratio as a prognostic factor for surgical resected non-small cell lung cancer: a population-based study
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Combining node location and node ratio as a prognostic factor for surgical resected non-small cell lung cancer: a population-based study

机译：结合节点位置和节点比作为外科切除的非小细胞肺癌的预后因素：基于人群的研究

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Background: In the TNM system only the anatomic location is used to define nodal status. In this study we aim to evaluate the effectiveness of combining the location and ratio of metastatic lymph node (pN-NR) for the prognosis of non-small cell lung cancer (NSCLC). Methods: Patients with pN1/pN2 NSCLC were retrieved from the SEER database. The optimal cut point of NR was determined with the maximal selecting test. All patients were divided into 4 categories with combination of pN (pN1 or pN2) and NR (low or high). The pN-NR was investigated as a predictor of overall survival (OS) and cause-specific survival (CSS) using Cox regression models. Survival curves were plotted using the Kaplan-Meier method and the difference was compared with log-rank test. Results: A total of 12,170 patients were enrolled. The optimal cut point of NR was 0.3. Patients were divided into 4 groups: pN1-NR 0.3, pN1-NR ≥0.3, pN2-NR 0.3 and pN2-NR ≥0.3. The pN-NR was an independent prognostic factor for survival. Compared with pN1-NR 0.3, the hazard ratio of OS was 1.405 (95% CI: 1.295–1.524), 1.183 (95% CI: 1.113–1257) and 1.717 (95% CI: 1.607–1.835) times higher for pN1-NR ≥0.3, pN2-NR 0.3 and pN2-NR ≥0.3 group, respectively. The survival curves of OS separated well between the 4 pN-NR groups, with 5-year OS 47.1% for pN1-NR 0.3, 43.0% for pN2-NR 0.3, 35.0% for pN1-NR ≥0.3 and 28.5% for pN2-NR ≥0.3, and the P value between neighboring curves was statistically significantly. The same trend was observed for CSS. Subgroup analysis revealed similar results except the pneumonectomy group. Conclusions: pN-NR could be a good predictor for the prognosis of NSCLC.
机译：背景：在TNM系统中，仅使用解剖位置来定义节点状态。在这项研究中，我们的目标是评估组合转移性淋巴结（PN-NR）的效果和比例用于非小细胞肺癌的预后（NSCLC）。方法：从SEER数据库中检索PN1 / PN2 NSCLC患者。使用最大选择测试测定NR的最佳切割点。所有患者均分为4个类别，组合PN（PN1或PN2）和NR（低或高）。使用COX回归模型研究了PN-NR作为总存活（OS）的预测因子和造成特异性存活（CSS）。使用Kaplan-Meier方法绘制生存曲线，并将差异与对数级测试进行比较。结果：共有12,170名患者。 NR的最佳切割点为0.3。患者分为4组：PN1-NR <0.3，PN1-NR≥0.3，PN2-NR <0.3和PN2-NR≥0.3。 PN-NR是生存期的独立预后因素。与PN1-NR <0.3相比，OS的危险比为1.405（95％CI：1.295-1.524），1.183（95％CI：1.113-1257）和1.717（95％CI：1.607-1.835），适用于PN1 -NR≥0.3，PN2-NR <0.3和PN2-NR≥0.3组。 OS的存活曲线在4 pN-NR组之间分离，PN1-NR <0.3,3.0％的5年OS 47.1％，PN2-NR <0.3,33.0％，PN1-NR≥0.3和28.5％的35.0％ PN2-NR≥0.3，邻近曲线之间的P值统计学显着。观察到CSS的相同趋势。亚组分析显示除肺切除术组外的类似结果。结论：PN-NR可能是NSCLC预后的良好预测因子。

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