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首页> 外文期刊>Journal of Thoracic Disease >The interstitial lung disease spectrum under a uniform diagnostic algorithm: a retrospective study of 1,945 individuals
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The interstitial lung disease spectrum under a uniform diagnostic algorithm: a retrospective study of 1,945 individuals

机译：均匀诊断算法下的间质肺病谱：1,945个个体的回顾性研究

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Background: Reported data on the disease spectrum of interstitial lung diseases (ILDs) of China are sparse and varied. We aimed to investigate the spectrum of ILDs and the distribution of diagnostic methods under a uniform diagnosis. Methods: This retrospective study enrolled ILDs cases from Guangzhou Institute of Respiratory Health (GIRH). All cases were classified into specific subgroups of ILDs according to updated guidelines. Results: A total of 1,945 subjects were enrolled from January 2012 to December 2017. The mean age was 57.9 years, and 1,080 (55.5%) patients were male. The most common subtype of ILDs was idiopathic pulmonary fibrosis (IPF, 20.3%), followed by interstitial pneumonia with autoimmune features (IPAF, 17.9%), connective tissue disease associated ILD (CTD-ILD, 18.3%) and unclassifiable idiopathic interstitial pneumonia (UIIP, 14.7%). A total of 818 (42.1%) patients underwent lung biopsy in order to obtain a histological diagnose. TBLB was performed in 565 (29.0%) patients, eleven of whom underwent SLB because TBLB failed to obtain lung samples. SLB was performed in 213 (11.0%) patients and TBCB was performed in 51 (2.6%) patients. Among them, histological results were considered clinically helpful in 722 (88.3%) cases, and provided definitive histopathological diagnoses in 368 cases. Surgical lung biopsy (SLB) was performed in 213 (10.9%) subjects, while 115 (54.0%) cases were performed among the idiopathic interstitial pneumonia (IIP). Among SLB cases in IIP, the highest rate of SLB was desquamative interstitial pneumonia/respiratory bronchiolitis-interstitial lung disease (DIP/RB-ILD, 10/10), lymphoid interstitial pneumonia (LIP, 9/9), followed by cryptogenic organizing (COP, 18/26), nonspecific interstitial pneumonia (NSIP, 22/53), IPF (43/395), UIIP (13/285). Conclusions: IPF was the most common ILDs in our ILD center, followed by IPAF, CTD-ILD and UIIP. Histological information may help to establish diagnostic algorithm in ILD.
机译：背景：报告了中国间质性肺病（ILD）的疾病谱的数据稀疏和各种各样。我们旨在调查均匀诊断下ILD的频谱和诊断方法的分布。方法：该回顾性研究注册了广州呼吸健康研究所（Girh）的ILDS病例。根据更新的指导方针，所有案例均分为ILD的特定子组。结果：2012年1月至2017年1月，共有1,945名受试者。平均年龄为57.9岁，1,080名（55.5％）是男性。最常见的ILD亚型是特发性肺纤维化（IPF，20.3％），其次是具有自身免疫特征（IPAF，17.9％），结缔组织疾病相关ILD（CTD-ILD，18.3％）和不可划分的特发性肺炎肠道（ UIIP，14.7％）。共有818例（42.1％）患者接受了肺活检，以获得组织学诊断。 TBLB是在565名（29.0％）患者中进行的，其中11名遭受了SLB的患者，因为TBLB未能获得肺样品。 SLB在213例（11.0％）患者中进行，TBCB在51例（2.6％）患者中进行。其中，组织学结果在722例（88.3％）病例中被认为是临床帮助，并在368例中提供了最终的组织病理学诊断。手术肺活检（SLB）在213例（10.9％）受试者中进行，而特发性间质肺炎（IIP）进行115例（54.0％）病例。在IIP中的SLB病例中，SLB的最高速率是脱位性间质肺炎/呼吸支气管炎 - 间质性肺病（DIP / RB-ILD，10/10），淋巴间质肺炎（唇，9/9），其次是密码组织（ COP，18/26），非特异性间质性肺炎（NSIP，22/53），IPF（43/395），UIIP（13/285）。结论：IPF是我们ILD中心中最常见的ILD，其次是IPAF，CTD-ILD和UIIP。组织学信息可能有助于在ILD中建立诊断算法。

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