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首页> 外文期刊>Journal of Thoracic Disease >Different treatment efficacies and side effects of cytotoxic chemotherapy
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Different treatment efficacies and side effects of cytotoxic chemotherapy

机译：细胞毒性化疗的不同治疗效率和副作用

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Differences in efficacy and toxicity between Asian and Caucasian patients with lung cancer treated with systemic chemotherapy is increasingly recognised. This is a major concern in the clinical setting as it influences outcomes and affect international harmonization of drug development. Interindividual variability of pharmacokinetics, where different genetic polymorphisms affect drug metabolism, transport, and receptor binding may account for the ethnic differences. Treatment efficacy and outcomes may also be explained by differences in diet and lifestyle, access to healthcare, cultural barriers and environmental exposure. Efforts made to design prospective studies investigating ethnic specific determinants to systemic therapy and individualise lung cancer treatment based on genetic makeup of patient are important.
机译：越来越识别患有全身化学疗法治疗的肺癌患者患有疗效和毒性的差异。这是临床环境中的主要问题，因为它会影响结果并影响药物发展的国际统一。药代动力学的细胞分子变异性，不同的遗传多态性影响药物代谢，运输和受体结合可能会占民族差异。治疗效率和结果也可以通过饮食和生活方式的差异来解释，获得医疗保健，文化障碍和环境暴露。为设计前瞻性研究调查种族特定决定因素和基于患者遗传构成的全身治疗和个性化肺癌治疗而努力。

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