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首页> 外文期刊>Journal of the Association of Physicians of India >A Pilot Study Evaluating the Effects of Diabetes Specific Nutrition Supplement and Lifestyle Intervention on Glycemic Control in Overweight and Obese Asian Indian Adults with Type 2 Diabetes Mellitus
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A Pilot Study Evaluating the Effects of Diabetes Specific Nutrition Supplement and Lifestyle Intervention on Glycemic Control in Overweight and Obese Asian Indian Adults with Type 2 Diabetes Mellitus

机译：试点研究评估糖尿病特异性营养补充和生活方式干预对超重和肥胖亚洲印度成人血糖控制的影响，2型糖尿病

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Background and Objectives: Medical nutrition therapy plays a crucial roleachievement of optimal glycemic control in individuals with diabetes. This studyaims to evaluate the effects of diabetes specific nutrition supplement (DSNS)along with lifestyle intervention in overweight and obese adults with Type 2Diabetes Mellitus (T2DM).Methods: A total of 120 overweight or obese individuals aged 30 – 65 yearswith T2DM, were randomly allocated to intervention (IG, n=60) and control (CG,n=60) groups in this 12-week study. All participants received dietary counsellingwith diet chart of 1400 kcal/day and recommendations for physical activity.DSNS was included in the dietary regimen adjusted within the daily calorierecommendations for intervention group. All participants were followed upmonthly for anthropometric, biochemical and clinical assessments. Continuousglucose monitoring was performed during the initial 2 weeks and last 2 weeksof the study in a sub- sample using Flash Glucose Monitoring device to studyglycemic excursions. Data was analyzed for the differences between interventionvs. control group using linear models.Results: Compared to the control group, the intervention group showedsignificant reduction in glycosylated haemoglobin (IG: -0.95% vs. CG: -0.48%;p=0.020) and fasting blood glucose (IG: -18.47 mg/dL vs. CG: 1.34mg/dL; p=0.03)as well as a greater reduction in postprandial plasma glucose (IG: -29.77mg/dL vs.CG: -2.64mg/dL; p=0.053). There was also a significant reduction from baselinein incremental Area under the Curve (iAUC) (p=0.01) in the intervention group(Δ -22 mg) compared to the control group (Δ -7.9 mg) with a correspondingreduction in the Mean Amplitude of Glycemic Excursion (MAGE) (P=0.04). Therewas no difference between groups in body weight, waist circumference, bloodpressure, and lipid profile. None of the subjects in the study reported seriousadverse events.Conclusion: This pilot study showed that a diabetes specific nutritionalsupplement was useful in improving glycemic control and reducing glycemicresponse in overweight and obese Asian Indian adults with T2DM.
机译：背景和目标：医疗营养治疗在糖尿病中的个体中发挥最佳血糖控制的关键roleafievement。这项研究员为了评估糖尿病特异性营养补充剂（DSN）的影响以及具有2型二割草（T2DM）的超重和肥胖成年人的生活方式干预。方法：总共120岁 - 65岁的肥胖或肥胖的人为T2DM，是随机的在该12周的研究中分配给干预（Ig，N = 60）和对照（CG，N = 60）组。所有参与者都收到了饮食咨询，饮食饮食图表为1400千卡/天，并将身体活动的建议包含在日常热电势的饮食方案中，为干预组进行调整。所有参与者都被关注，用于人体测量，生化和临床评估。在初始2周期间进行连续葡萄糖监测，并在使用闪光葡萄糖监测装置到学习血糖偏移的子样本中的研究中进行的最后2周。分析数据的差异之间的差异。对照组使用线性模型。结果：与对照组相比，干预组在糖基化血红蛋白（Ig：-0.95％Vs.CG：-0.48％; P = 0.020）和空腹血糖（Ig：-18.47mg / DL对CG：1.34mg / dL; p = 0.03）以及餐后血浆葡萄糖的更大减少（Ig：-29.77mg / dl Vs.cg：-2.64mg / dl; p = 0.053）。与对照组（δ-22mg）相比，在介入组（δ-22mg）中的曲线（IAC）（p = 0.01）下的基线增量面积显着减少（Δ-7.9mg），其平均幅度相应血糖偏移（法师）（P = 0.04）。因此，体重，腰围，血压和脂质剖面的组之间没有差异。该研究中的主题都没有报告了严重事件。结论：这项试验研究表明，糖尿病特异性营养化合物在改善血糖对照和减少具有T2DM的超重和肥胖亚洲印度成人中的血糖控制和降低血糖响应。

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