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首页> 外文期刊>Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland >In vitro activity of antimicrobial agents against multidrug- and extensively drug-resistant Acinetobacter baumannii
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In vitro activity of antimicrobial agents against multidrug- and extensively drug-resistant Acinetobacter baumannii

机译：抗微生物剂对抗微粒和广泛的耐药性的抗菌药物的体外活性Baumannii

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Acinetobacter baumannii is a leading cause of complicatedinfections in the hospital environment, particularly amongseverely ill patients [1]. The crude mortality attributed toAcinetobacter species causing bloodstream infections ishigher than 50% [2]. Carbapenems have been one of themain antimicrobial classes used against A. baumannii infec-tions [3], but the emergence and dissemination of carbape-nemases have diminished the utility of this class of drugsfrom an already limited list of existing treatment options[4]. In Brazil, it is known that carbapenem-resistant A. bau-mannii is considered endemic [5], and the main lineagescirculating in that country are those belonging to the clonalcomplexes (CCs) CC1, CC15 and CC79 [6, 7]. Among thealternatives for the treatment of infections due to carbape-nem-resistant A. baumannii, polymyxins and other non-b-lactam agents, such as tetracyclines, may be valuable options[3]. Given the increasing rates of multidrug- (MDR) andextensively drug-resistant (XDR) A. baumannii [8], deter-mination of the antimicrobial susceptibility of alternativeagents is needed to assess the availability of potential thera-peutic options. Thus, the aim of this study was to assess thein vitro activity of antimicrobial agents against carbapenem-resistant A. baumannii isolates recovered from clinicalspecimens of patients from several hospitals in the state ofS~ ao Paulo, Brazil.
机译：AcineTobacter Baumannii是医院环境中复杂性的主要原因，特别是患者中的复杂性患者[1]。原子死亡率归因于特异性，导致血液感染的物种比50％高，[2]。 Carbapenems是针对A. Baumannii Infec-tions的抗微生物类别之一[3]，但Carbape-Nemases的出现和传播已经在已经有限的现有治疗方案列表中减少了这类药物的效用[4]。在巴西，众所周知，耐鲤鱼抗A. Bau-mannii被认为是地方性[5]，并且该国家的主要线程是属于克隆复印件（CCS）CC1，CC15和CC79 [6,7]的主要线程。由于耐药NEM抗性A.Baumannii，多粘蛋白和其他非B-lactam试剂（例如四环素）的杀菌剂中，如四环素，可能是有价值的选择[3]。鉴于多rDrug-（MDR）且抗毒性（XDR）A.Baumannii [8]的较高率，需要对交别的抗微生物敏感性进行造成，以评估潜在的Thera实验选择的可用性。因此，本研究的目的是评估抗菌药物对抗菌剂的体外活性对耐肉豆蔻抗性A. Baumannii分离物从巴西的近几家医院的患者患者的临床企鹅中回收。

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