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首页> 外文期刊>BMC Cancer >A multicenter study investigating the molecular fingerprint of psychological resilience in breast cancer patients: study protocol of the SCAN-B resilience study
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A multicenter study investigating the molecular fingerprint of psychological resilience in breast cancer patients: study protocol of the SCAN-B resilience study

机译：调查乳腺癌患者心理韧带分子指纹的多中心研究：SCAN-B恢复研究的研究方案

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Individual patients differ in their psychological response when receiving a cancer diagnosis, in this case breast cancer. Given the same disease burden, some patients master the situation well, while others experience a great deal of stress, depression and lowered quality of life. Patients with high psychological resilience are likely to experience fewer stress reactions and better adapt to and manage the life threat and the demanding treatment that follows the diagnosis. If this phenomenon of mastering difficult situations is reflected also in biomolecular processes is not much studied, nor has its capacity for impacting the cancer prognosis been addressed. This project specifically aims, for the first time, to investigate how a breast cancer patient's psychological resilience is coupled to biomolecular parameters using advanced "omics" and, as a secondary aim, whether it relates to prognosis and quality of life one year after diagnosis. The study population consists of newly diagnosed breast cancer patients enrolled in the Sweden Cancerome Analysis Network - Breast (SCAN-B) at four hospitals in Sweden. At the time of cancer diagnosis, the patient fills out the standardized method to measure psychological resilience, the "Connor-Davidson Resilience scale" (CD-RISC), the quality of life measure SF-36, as well as providing social and socioeconomic variables. In addition, one blood sample is collected. At the one-year follow-up, the patient will be subjected to the same assessments, and we also collect information regarding smoking, exercise habits, and BMI, as well as patients' trust in the treatment and their satisfaction with the care and treatment. This explorative hypothesis-generating project will pave the way for larger validation studies, potentially leading to a standardized method of measuring psychological resilience as an important parameter in cancer care. Revealing the body-mind interaction, in terms of psychological resilience and quality of life, will herald the development of truly personalized psychosocial care and cancer intervention treatment strategies. This is a retrospectively registered trial at ClinicalTrials.gov, ID: NCT03430492 on February 6, 2018.
机译：在这种情况下，单个患者在这种情况下，在这种情况下，在这种情况下患癌症诊断的心理反应不同。鉴于同样的疾病负担，有些患者掌握了这种情况，而其他患者则经历了大量的压力，抑郁和降低的生活质量。心理韧性高的患者可能会越来越少的压力反应，更好地适应并管理诊断的生命威胁和苛刻的治疗。如果在生物分子过程中也反映了掌握困难情况的这种现象并没有很多研究，也没有其影响癌症预后的能力。该项目专门针对使用先进的“OMIC”的乳腺癌患者的心理弹性如何与生物分子参数联系起来，作为诊断后一年的预后和生命质量涉及到生物分子参数。该研究人群由新诊断的乳腺癌患者组成，在瑞典的四家医院招募瑞典癌症分析网络 - 乳房（Scan-B）。在癌症诊断时，患者填写标准化方法来测量心理弹性，“CONNOR-DAVIDSON弹性量表”（CD-RISC），生活质量测量SF-36，以及提供社会和社会经济变量。此外，收集一个血液样品。在一年的随访时，患者将进行同一评估，我们还收集有关吸烟，行使习惯和BMI的信息，以及患者对治疗的信任及其对护理和治疗的满意度。这种探索性假设产生项目将为更大的验证研究铺平道路，可能导致标准化方法测量心理恢复能力作为癌症护理中的重要参数。在心理韧性和生活质量方面，揭示身心互动，将制定真正个性化的心理社会护理和癌症干预治疗策略的发展。这是在ClinColicalTrials.gov的回顾性注册试验，ID：2018年2月6日的NCT03430492。

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