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首页> 外文期刊>BMC Cancer >Construction of an integrated human osteosarcoma database, HOsDb, based on literature mining, microarray analysis, and database retrieval
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Construction of an integrated human osteosarcoma database, HOsDb, based on literature mining, microarray analysis, and database retrieval

机译：基于文献挖掘，微阵列分析和数据库检索，构建综合人体骨肉瘤数据库，HOSDB

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BACKGROUND:Osteosarcoma (OS) is the most frequent primary malignancy of bone with a high incidence in adolescence. This study aimed to construct a publicly available, integrated database of human OS, named HOsDb.METHODS:Microarray data, current databases, and a literature search of PubMed were used to extract information relevant to human OS-related genes and their transcription factors (TFs) and single nucleotide polymorphisms (SNPs), as well as methylation sites and microRNAs (miRNAs). This information was collated for constructing the HOsDb.RESULTS:In total, we identified 7191 OS tumor-related genes, 763 OS metastasis-related genes, and 1589 OS drug-related genes, corresponding to 190,362, 21,131, and 41,135 gene-TF pairs, respectively, 3,749,490, 358,361, and 767,674 gene-miRNA pairs, respectively; and 28,386, 2532, and 3943 SNPs, respectively. Additionally, 240 OS-related miRNAs, 1695 genes with copy number variations in OS, and 18 genes with methylation sites in OS were identified. These data were collated to construct the HOsDb, which is available at www.hosdatabase.com. Users can search OS-related molecules using this database.CONCLUSION:The HOsDb provides a platform that is comprehensive, quick, and easily accessible, and it will enrich our current knowledge of OS.
机译：背景：Osteosarcoma（OS）是骨骼中最常见的是青春期发病率高的骨骼的主要恶性肿瘤。本研究旨在构建名为Hosdb.methods的公共可用的人体OS的集成数据库：微阵列数据，当前数据库和Pubmed的文献搜索，用于提取与人类OS相关基因相关的信息及其转录因子（TFS ）和单核苷酸多态性（SNP），以及甲基化位点和MicroRNA（miRNA）。该信息进行了构建HOSDB.Results：总共确定了7191个OS肿瘤相关基因，763 os转移相关基因和1589个与药物相关基因，对应于190,362,21,131和41,135基因-TF对。分别为3,749,490,358,361和767,674个基因 - miRNA对;和28,386,2532和3943个SNP。另外，鉴定了240个与OS相关的MIRNA，1695个基因，OS拷贝数变化和OS中的甲基化位点的18个基因。这些数据被整理为构造HOSDB，可在www.hosdatabase.com上获得。用户可以使用此数据库搜索与操作系统相关的分子。配置：HOSDB提供全面，快速，轻松访问的平台，并将丰富我们目前的OS知识。

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