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首页> 外文期刊>BMC Public Health >Prevalence, incidence, and risk factors of primary open-angle glaucoma - a cohort study based on longitudinal data from a German public health insurance
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Prevalence, incidence, and risk factors of primary open-angle glaucoma - a cohort study based on longitudinal data from a German public health insurance

机译：主要开放角青光眼的患病率，发病率和危险因素 - 基于来自德国公共卫生保险的纵向数据的队列研究

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This study estimates the prevalence and incidence rates of primary open -angle glaucoma (POAG) as well as risk factors based on a dataset from the largest German health insurance company. A random sample of 250,000 persons at age 50+ of the Allgemeine Ortskrankenkasse (AOK) from 2010 to 2013 was used. Selected risk factors of POAG incidence were analyzed using multivariate Cox proportional hazard models. The age-standardized prevalence of POAG at age 50+ in 2010 was 2.79% (95%-CI: 2.72-2.85%). The age-standardized total incidence rate was 0.38 (0.36-0.39) per 100 person-years. Sex differences were significant for total prevalence and total incidence rates, with higher prevalence and incidence rates for women compared to men. The Cox model revealed a strong age effect, a significantly 19% higher incidence for women (p?≤?0.001), injuries of the eye and orbit (175%, p?≤?0.001), degeneration of iris and ciliary body (155%, p?=?0.022), myopia (155%, p?≤?0.001), retinal vascular occlusions (134%, p?≤?0.001), hypertension (13%, p?≤?0.001) and diabetes mellitus (23%, p?≤?0.001). Health claims data are an important data source for estimating POAG occurrence and help overcome the problems of small sample sizes. These results may help to understand the causal pathways of POAG and to develop intervention strategies to increase the awareness of patients and physicians with the aim of reducing POAG incidence.
机译：本研究估计，基于最大的德国健康保险公司的数据集的原发性开放性 - 突出的患病率和发病率以及危险因素。从2010年到2013年，使用了来自2010年至2013年的Allgemeine Ortskrankenkasse（AOK）的250,000人的随机样本。使用多元Cox比例危险模型分析了采取的小册子发病率的危险因素。 2010年龄50岁以上的POAG的年龄标准化患病率为2.79％（95％-ci：2.72-2.85％）。年龄标准化的总发病率为每100人的0.38（0.36-0.39）。性差异对于总患病率和总发病率较高，与男性相比，女性的流行率和发病率较高。 Cox模型揭示了强烈的年龄效应，对女性的发病率较高（P？≤≤001），眼睛损伤和轨道损伤（175％，p≤≤0.001），虹膜和睫状体的退化（155 ％，p？= 0.022），近视（155％，p≤≤0.001），视网膜血管闭塞（134％，p≤≤0.001），高血压（13％，p？≤α0.001）和糖尿病（ 23％，p？≤≤0.001）。健康声称数据是用于估算Poog事件的重要数据源，并有助于克服小样本尺寸的问题。这些结果可能有助于了解POAG的因果通道，并制定干预策略，以提高患者和医生的意识，以减少作业率。

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