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首页> 外文期刊>BMC Public Health >The moderating effect of childhood disadvantage on the associations between smoking and occupational exposure and lung function; a cross sectional analysis of the UK Household Longitudinal Study (UKHLS)
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The moderating effect of childhood disadvantage on the associations between smoking and occupational exposure and lung function; a cross sectional analysis of the UK Household Longitudinal Study (UKHLS)

机译：儿童时期缺点对吸烟与职业暴露与肺功能联想的调节效果;英国家庭纵向研究的横截面分析（UKHLS）

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Lung function is lower in people with disadvantaged socio-economic position (SEP) and is associated with hazardous health behaviours and exposures. The associations are likely to be interactive, for example, exposure to socially patterned environmental tobacco smoke (ETS) in childhood is associated with an increased effect of smoking in adulthood. We hypothesise that disadvantaged childhood SEP increases susceptibility to the effects of hazards in adulthood for lung function. We test whether disadvantaged childhood SEP moderates smoking, physical activity, obesity, occupational exposures, ETS and air pollution's associations with lung function. Data are from the Nurse Health Assessment (NHA) in waves two and three of the United Kingdom Household Longitudinal Study (UKHLS). Analysis is restricted to English residents aged at least 20 for women and 25 for men, producing a study population of 16,339. Lung function is measured with forced expiratory volume in the first second (FEV1) and standardised to the percentage of expected FEV1 for a healthy non-smoker of equivalent age, gender, height and ethnicity (FEV1%). Using STATA 14, a mixed linear model was fitted with interaction terms between childhood SEP and health behaviours and occupational exposures. Cross level interactions tested whether childhood SEP moderated household ETS and neighbourhood air pollution's associations with FEV1%. SEP, smoking, physical activity, obesity, occupational exposures and air pollution were associated with lung function. Interaction terms indicated a significantly stronger negative association between disadvantaged childhood SEP and currently smoking (coefficient -6.47 %, 95% confidence intervals (CI): 9.51 %, 3.42 %) as well as with formerly smoking and occupational exposures. Significant interactions were not found with physical activity, obesity, ETS and air pollution. The findings suggest that disadvantaged SEP in childhood may make people's lung function more susceptible to the negative effects of smoking and occupational exposures in adulthood. This is important as those most likely to encounter these exposures are at greater risk to their effects. Policy to alleviate this inequality requires intervention in health behaviours through public health campaigns and in occupational health via health and safety legislation.
机译：肺功能较低的社会经济地位（SEP），与危险的健康行为和暴露有关。例如，关联可能是互动的，例如，儿童时期的社会图案化的环境烟草烟雾（ETS）与Afulthood吸烟的效果增加有关。我们假设弱势儿童SEP增加了对成年为肺功能的危害影响的敏感性。我们测试是否处于弱势儿童SEP调节吸烟，身体活动，肥胖，职业暴露，ETS和空气污染与肺功能的关联。数据来自英国家庭纵向研究（UKHLS）的波浪二和三个中的护士健康评估（NHA）。分析仅限于男性和25岁时至少20岁的英国居民，产生16,339人的研究人口。肺功能在第一秒（FEV1）中用强制呼气量测量，并标准化为预期FEV1的百分比，以获得同等年龄，性别，高度和种族的健康非吸烟者（FEV1％）。使用Stata 14，混合线性模型配有儿童SEP和健康行为和职业暴露之间的相互作用术语。交叉水平互动测试是否儿童SEP适度的家庭ETS和邻域空气污染的关联与FEV1％。 SEP，吸烟，身体活动，肥胖，职业暴露和空气污染与肺功能有关。相互作用术语表明弱势儿童患病和目前吸烟之间的显着更强的负关联（系数-6.47％，95％的置信区间（CI）：9.51％，3.42％）以及以前的吸烟和职业暴露。身体活动，肥胖，ETS和空气污染没有发现显着的相互作用。研究结果表明，儿童时期的弱势症可能会使人们的肺功能更容易受到成年人吸烟和职业暴露的负面影响。这是重要的，因为最有可能遇到这些暴露的风险更大。减轻这种不平等的政策需要通过卫生和安全立法通过公共卫生运动和职业健康干预健康行为。

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